Cargando…

Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes

BACKGROUND: Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/or phenotype to the surrounding environment. Hyper-virulent streptococcal pyr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shumba, Patience, Sura, Thomas, Moll, Kirsten, Chakrakodi, Bhavya, Tölken, Lea A., Hoßmann, Jörn, Hoff, Katharina J., Hyldegaard, Ole, Nekludov, Michael, Svensson, Mattias, Arnell, Per, Skrede, Steinar, Norrby-Teglund, Anna, Siemens, Nikolai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331992/ https://www.ncbi.nlm.nih.gov/pubmed/37430325 http://dx.doi.org/10.1186/s12929-023-00947-x

Ejemplares similares

SpeB of Streptococcus pyogenes Differentially Modulates Antibacterial and Receptor Activating Properties of Human Chemokines
por: Egesten, Arne, et al.
Publicado: (2009)

Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections
por: Siemens, Nikolai, et al.
Publicado: (2015)

Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
por: Movert, Elin, et al.
Publicado: (2023)

Streptococcus pyogenes c-di-AMP Phosphodiesterase, GdpP, Influences SpeB Processing and Virulence
por: Cho, Kyu Hong, et al.
Publicado: (2013)

Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study
por: Bruun, Trond, et al.
Publicado: (2020)

Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production
por: Westman, Johannes, et al.
Publicado: (2018)

EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity
por: Allhorn, Maria, et al.
Publicado: (2008)

The Dlt and LiaFSR systems derepress SpeB production independently in the Δpde2 mutant of Streptococcus pyogenes
por: Faozia, Sabrina, et al.
Publicado: (2023)

Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study
por: Hansen, Marco Bo, et al.
Publicado: (2017)

Consistent Biofilm Formation by Streptococcus pyogenes emm 1 Isolated From Patients With Necrotizing Soft Tissue Infections
por: Skutlaberg, Dag Harald, et al.
Publicado: (2022)

Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections
por: Palma Medina, Laura M., et al.
Publicado: (2021)

Deletion of the L-Lactate Dehydrogenase Gene ldh in Streptococcus pyogenes Leads to a Loss of SpeB Activity and a Hypovirulent Phenotype
por: Oehmcke-Hecht, Sonja, et al.
Publicado: (2017)

Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
por: Thänert, Robert, et al.
Publicado: (2019)

Molecular Cloning and Docking of speB Gene Encoding Cysteine Protease With Antibiotic Interaction in Streptococcus pyogenes NBMKU12 From the Clinical Isolates
por: Balasubramanian, Natesan, et al.
Publicado: (2018)

RopB represses the transcription of speB in the absence of SIP in group A Streptococcus
por: Chiang-Ni, Chuan, et al.
Publicado: (2023)

Retraction: Molecular Cloning and Docking of speB Gene Encoding Cysteine Protease With Antibiotic Interaction in Streptococcus pyogenes NBMKU12 From the Clinical Isolates
Publicado: (2018)

Srv Mediated Dispersal of Streptococcal Biofilms Through SpeB Is Observed in CovRS+ Strains
por: Connolly, Kristie L., et al.
Publicado: (2011)

Proteolytic Profiling of Streptococcal Pyrogenic Exotoxin B (SpeB) by Complementary HPLC-MS Approaches
por: Blöchl, Constantin, et al.
Publicado: (2021)

Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse
por: Chella Krishnan, Karthickeyan, et al.
Publicado: (2016)

Group A Streptococcus Vaccine Targeting the Erythrogenic Toxins SpeA and SpeB Is Safe and Immunogenic in Rabbits and Does Not Induce Antibodies Associated with Autoimmunity
por: Troese, Matthew J., et al.
Publicado: (2023)

Streptococcal SpeB Cleaved PAR-1 Suppresses ERK Phosphorylation and Blunts Thrombin-Induced Platelet Aggregation
por: Ender, Miriam, et al.
Publicado: (2013)

Differences in SpeB protease activity among group A streptococci associated with superficial, invasive, and autoimmune disease
por: Ly, Anhphan T., et al.
Publicado: (2017)

Suicide signaling by GSDMA: a single-molecule mechanism for recognition and defense against SpeB-expressing GAS
por: Symmank, Judit, et al.
Publicado: (2022)

Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
por: Jahagirdar, Sanjeevan, et al.
Publicado: (2022)

Allelic replacement of the streptococcal cysteine protease SpeB in a Δsrv mutant background restores biofilm formation
por: Roberts, Amity L, et al.
Publicado: (2010)

Dispersal of Group A Streptococcal Biofilms by the Cysteine Protease SpeB Leads to Increased Disease Severity in a Murine Model
por: Connolly, Kristie L., et al.
Publicado: (2011)

Repression of Rgg But Not Upregulation of LacD.1 in emm1-type covS Mutant Mediates the SpeB Repression in Group A Streptococcus
por: Chiang-Ni, Chuan, et al.
Publicado: (2016)

The Streptococcal Protease SpeB Antagonizes the Biofilms of the Human Pathogen Staphylococcus aureus USA300 through Cleavage of the Staphylococcal SdrC Protein
por: Carothers, Katelyn E., et al.
Publicado: (2020)

Sequence variability is correlated with weak immunogenicity in Streptococcus pyogenes M protein
por: Lannergård, Jonas, et al.
Publicado: (2015)

A Naturally Occurring Mutation in ropB Suppresses SpeB Expression and Reduces M1T1 Group A Streptococcal Systemic Virulence
por: Hollands, Andrew, et al.
Publicado: (2008)

RopB-regulated SpeB cysteine protease degrades extracellular vesicles-associated streptolysin O and bacterial proteins from group A Streptococcus
por: Chiang-Ni, Chuan, et al.
Publicado: (2023)

Structure of the E. coli agmatinase, SPEB
por: Chitrakar, Iva, et al.
Publicado: (2021)

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome
por: Emgård, Johanna, et al.
Publicado: (2019)

HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes
por: Johansson, Linda, et al.
Publicado: (2014)

Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo
por: Westman, Johannes, et al.
Publicado: (2015)

Antibodies against a Surface Protein of Streptococcus pyogenes Promote a Pathological Inflammatory Response
por: Kahn, Fredrik, et al.
Publicado: (2008)

The Role of Streptococcal and Staphylococcal Exotoxins and Proteases in Human Necrotizing Soft Tissue Infections
por: Shumba, Patience, et al.
Publicado: (2019)

Intracellular Streptococcus pyogenes in Human Macrophages Display an Altered Gene Expression Profile
por: Hertzén, Erika, et al.
Publicado: (2012)

Clinical Characteristics and Histopathology in Suspected Necrotizing Soft Tissue Infections
por: Gundersen, Ingunn M, et al.
Publicado: (2022)

Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology
por: Mairpady Shambat, Srikanth, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_oqio1b6qi62dtsa4q72n9jk5q9