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The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer

BACKGROUND: Protein phosphatase 2A (PP2A) is one of the major protein phosphatases in eukaryotic cells and is essential for cellular homeostasis. PP2A is a heterotrimer comprising the dimeric AC core enzyme and a highly variable regulatory B subunit. Distinct B subunits help the core enzyme gain ful...

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Detalles Bibliográficos
Autores principales:	Hsiao, Kai-Ching, Ruan, Siou-Ying, Chen, Shih-Min, Lai, Tai-Yu, Chan, Ren-Hao, Zhang, Yan-Ming, Chu, Chien-An, Cheng, Hung-Chi, Tsai, Hung-Wen, Tu, Yi-Fang, Law, Brian K., Chang, Ting-Tsung, Chow, Nan-Haw, Chiang, Chi-Wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332018/ https://www.ncbi.nlm.nih.gov/pubmed/37430297 http://dx.doi.org/10.1186/s12964-023-01182-5

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