Do vaccinations influence the development of Alzheimer disease?

A growing literature supports a protective association between vaccines targeting an array of pathogens (e.g., influenza, pneumococcus, herpes zoster) and the risk of Alzheimer disease (AD). This article discusses the potential underlying mechanisms for this apparent protective effect of immunizatio...

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Autores principales: Bukhbinder, Avram S., Ling, Yaobin, Harris, Kristofer, Jiang, Xiaoqian, Schulz, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Public Health & Policy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332212/
https://www.ncbi.nlm.nih.gov/pubmed/37291109
http://dx.doi.org/10.1080/21645515.2023.2216625
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author Bukhbinder, Avram S.
Ling, Yaobin
Harris, Kristofer
Jiang, Xiaoqian
Schulz, Paul E.
author_facet Bukhbinder, Avram S.
Ling, Yaobin
Harris, Kristofer
Jiang, Xiaoqian
Schulz, Paul E.
author_sort Bukhbinder, Avram S.
collection PubMed
description A growing literature supports a protective association between vaccines targeting an array of pathogens (e.g., influenza, pneumococcus, herpes zoster) and the risk of Alzheimer disease (AD). This article discusses the potential underlying mechanisms for this apparent protective effect of immunizations against infectious pathogens on the risk of AD; explores the basic and pharmacoepidemiologic evidence for this association, with particular attention paid to important methodological variations among the epidemiologic studies; and reviews the remaining uncertainties regarding the effects of anti-pathogen vaccines on Alzheimer disease and all-cause dementia, with recommendations for future directions to address those uncertainties.
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spelling pubmed-103322122023-07-11 Do vaccinations influence the development of Alzheimer disease? Bukhbinder, Avram S. Ling, Yaobin Harris, Kristofer Jiang, Xiaoqian Schulz, Paul E. Hum Vaccin Immunother Public Health & Policy A growing literature supports a protective association between vaccines targeting an array of pathogens (e.g., influenza, pneumococcus, herpes zoster) and the risk of Alzheimer disease (AD). This article discusses the potential underlying mechanisms for this apparent protective effect of immunizations against infectious pathogens on the risk of AD; explores the basic and pharmacoepidemiologic evidence for this association, with particular attention paid to important methodological variations among the epidemiologic studies; and reviews the remaining uncertainties regarding the effects of anti-pathogen vaccines on Alzheimer disease and all-cause dementia, with recommendations for future directions to address those uncertainties. Taylor & Francis 2023-06-08 /pmc/articles/PMC10332212/ /pubmed/37291109 http://dx.doi.org/10.1080/21645515.2023.2216625 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Public Health & Policy
Bukhbinder, Avram S.
Ling, Yaobin
Harris, Kristofer
Jiang, Xiaoqian
Schulz, Paul E.
Do vaccinations influence the development of Alzheimer disease?
title Do vaccinations influence the development of Alzheimer disease?
title_full Do vaccinations influence the development of Alzheimer disease?
title_fullStr Do vaccinations influence the development of Alzheimer disease?
title_full_unstemmed Do vaccinations influence the development of Alzheimer disease?
title_short Do vaccinations influence the development of Alzheimer disease?
title_sort do vaccinations influence the development of alzheimer disease?
topic Public Health & Policy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332212/
https://www.ncbi.nlm.nih.gov/pubmed/37291109
http://dx.doi.org/10.1080/21645515.2023.2216625
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