EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance

Of the β-cell signaling pathways altered by obesity and insulin resistance, some are adaptive while others contribute to β-cell failure. Two critical second messengers are Ca(2+) and cAMP, which control the timing and amplitude of insulin secretion. Previous work has shown the importance of the cAMP...

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Detalles Bibliográficos
Autores principales: Schaid, Michael D., Harrington, Jeffrey M., Kelly, Grant M., Sdao, Sophia M., Merrins, Matthew J., Kimple, Michelle E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332234/
https://www.ncbi.nlm.nih.gov/pubmed/37415404
http://dx.doi.org/10.1080/19382014.2023.2223327

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