Calcineurin Inhibitor-Induced Type IV Renal Tubular Acidosis in Post-Bone Marrow Transplant: Review of Pathophysiology and Principles of Management

Calcineurin inhibitors (CNI) are the mainstay of immunosuppressant medications in both bone marrow transplants and solid organ transplants. Nephrotoxicity is a well-known adverse effect of this group. Type IV renal tubular acidosis is a potentially under-recognized complication. Here we report a cas...

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Autores principales: AL-Omairi, Anwar, Abdulnasser Obaid, Mohammed, Agrawal, Indira, Abdalla, Amr, Al Rawas, Abdul Hakim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332329/
https://www.ncbi.nlm.nih.gov/pubmed/37435251
http://dx.doi.org/10.7759/cureus.40215
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author AL-Omairi, Anwar
Abdulnasser Obaid, Mohammed
Agrawal, Indira
Abdalla, Amr
Al Rawas, Abdul Hakim
author_facet AL-Omairi, Anwar
Abdulnasser Obaid, Mohammed
Agrawal, Indira
Abdalla, Amr
Al Rawas, Abdul Hakim
author_sort AL-Omairi, Anwar
collection PubMed
description Calcineurin inhibitors (CNI) are the mainstay of immunosuppressant medications in both bone marrow transplants and solid organ transplants. Nephrotoxicity is a well-known adverse effect of this group. Type IV renal tubular acidosis is a potentially under-recognized complication. Here we report a case of Omenn syndrome in a patient who underwent a bone marrow transplant and developed type IV renal tubular acidosis while on treatment with cyclosporine.
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spelling pubmed-103323292023-07-11 Calcineurin Inhibitor-Induced Type IV Renal Tubular Acidosis in Post-Bone Marrow Transplant: Review of Pathophysiology and Principles of Management AL-Omairi, Anwar Abdulnasser Obaid, Mohammed Agrawal, Indira Abdalla, Amr Al Rawas, Abdul Hakim Cureus Pediatrics Calcineurin inhibitors (CNI) are the mainstay of immunosuppressant medications in both bone marrow transplants and solid organ transplants. Nephrotoxicity is a well-known adverse effect of this group. Type IV renal tubular acidosis is a potentially under-recognized complication. Here we report a case of Omenn syndrome in a patient who underwent a bone marrow transplant and developed type IV renal tubular acidosis while on treatment with cyclosporine. Cureus 2023-06-10 /pmc/articles/PMC10332329/ /pubmed/37435251 http://dx.doi.org/10.7759/cureus.40215 Text en Copyright © 2023, AL-Omairi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
AL-Omairi, Anwar
Abdulnasser Obaid, Mohammed
Agrawal, Indira
Abdalla, Amr
Al Rawas, Abdul Hakim
Calcineurin Inhibitor-Induced Type IV Renal Tubular Acidosis in Post-Bone Marrow Transplant: Review of Pathophysiology and Principles of Management
title Calcineurin Inhibitor-Induced Type IV Renal Tubular Acidosis in Post-Bone Marrow Transplant: Review of Pathophysiology and Principles of Management
title_full Calcineurin Inhibitor-Induced Type IV Renal Tubular Acidosis in Post-Bone Marrow Transplant: Review of Pathophysiology and Principles of Management
title_fullStr Calcineurin Inhibitor-Induced Type IV Renal Tubular Acidosis in Post-Bone Marrow Transplant: Review of Pathophysiology and Principles of Management
title_full_unstemmed Calcineurin Inhibitor-Induced Type IV Renal Tubular Acidosis in Post-Bone Marrow Transplant: Review of Pathophysiology and Principles of Management
title_short Calcineurin Inhibitor-Induced Type IV Renal Tubular Acidosis in Post-Bone Marrow Transplant: Review of Pathophysiology and Principles of Management
title_sort calcineurin inhibitor-induced type iv renal tubular acidosis in post-bone marrow transplant: review of pathophysiology and principles of management
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332329/
https://www.ncbi.nlm.nih.gov/pubmed/37435251
http://dx.doi.org/10.7759/cureus.40215
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