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Cryptococcosis in Southern China: Insights from a Six-Year Retrospective Study in Eastern Guangdong
OBJECTIVE: Cryptococcosis is a fatal infection that can affect both immunocompetent and immunocompromised patients, and it is little understood in China’s various regions. This research aimed to look at the epidemiology, risk factors, and antifungal susceptibility pattern of Cryptococcus neoformans...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332366/ https://www.ncbi.nlm.nih.gov/pubmed/37435235 http://dx.doi.org/10.2147/IDR.S417968 |
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author | Bilal, Hazrat Zhang, Dongxing Shafiq, Muhammad Khan, Muhammad Nadeem Chen, Canhua Khan, Sabir Wang, Qian Cai, Lin Awais, Muhammad Hu, Haibin Zeng, Yuebin |
author_facet | Bilal, Hazrat Zhang, Dongxing Shafiq, Muhammad Khan, Muhammad Nadeem Chen, Canhua Khan, Sabir Wang, Qian Cai, Lin Awais, Muhammad Hu, Haibin Zeng, Yuebin |
author_sort | Bilal, Hazrat |
collection | PubMed |
description | OBJECTIVE: Cryptococcosis is a fatal infection that can affect both immunocompetent and immunocompromised patients, and it is little understood in China’s various regions. This research aimed to look at the epidemiology, risk factors, and antifungal susceptibility pattern of Cryptococcus neoformans in eastern Guangdong, China. METHODS: A six-year (2016–2022) retrospective study was conducted at Meizhou People’s Hospital, China. Demographical, clinical, and laboratory data of cryptococcal patients were collected from hospital records and statistically analyzed using the chi-square and ANOVA tests. RESULTS: Overall, 170 cryptococcal infections were recorded, of which meningitis accounted for 78 (45.88%), cryptococcemia for 50 (29.41%), and pneumonia for 42 (24.7%). The number of cases increased 8-fold during the study duration. The median age of patients was 58 years (Inter quartile range: 47–66), and the high proportion of cases was from the male population (n = 121, 71.17%). The underlying diseases were identified only in 60 (35.29%) patients, of which 26 (15.29%) were severely immunocompromised, and 26 (15.29%) others were mildly immunocompromised. A statistically significant difference was reported for chronic renal failure, and anemia (p < 0.05) persisted in cases of three infection types. A high number of non-wild type (NWT) isolates were found against amphotericin B (n=13/145, 8.96%), followed by itraconazole (n=7/136, 5.15%) and voriconazole (n=4/158, 2.53%). Only six isolates (3.79%) were multidrug-resistant, four of which were from cryptococcemia patients. Compared to meningitis and pneumonia, cryptococcemia revealed a higher percentage of NWT isolates (p < 0.05). CONCLUSION: In high-risk populations, cryptococcal infections require ongoing monitoring and management. |
format | Online Article Text |
id | pubmed-10332366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-103323662023-07-11 Cryptococcosis in Southern China: Insights from a Six-Year Retrospective Study in Eastern Guangdong Bilal, Hazrat Zhang, Dongxing Shafiq, Muhammad Khan, Muhammad Nadeem Chen, Canhua Khan, Sabir Wang, Qian Cai, Lin Awais, Muhammad Hu, Haibin Zeng, Yuebin Infect Drug Resist Original Research OBJECTIVE: Cryptococcosis is a fatal infection that can affect both immunocompetent and immunocompromised patients, and it is little understood in China’s various regions. This research aimed to look at the epidemiology, risk factors, and antifungal susceptibility pattern of Cryptococcus neoformans in eastern Guangdong, China. METHODS: A six-year (2016–2022) retrospective study was conducted at Meizhou People’s Hospital, China. Demographical, clinical, and laboratory data of cryptococcal patients were collected from hospital records and statistically analyzed using the chi-square and ANOVA tests. RESULTS: Overall, 170 cryptococcal infections were recorded, of which meningitis accounted for 78 (45.88%), cryptococcemia for 50 (29.41%), and pneumonia for 42 (24.7%). The number of cases increased 8-fold during the study duration. The median age of patients was 58 years (Inter quartile range: 47–66), and the high proportion of cases was from the male population (n = 121, 71.17%). The underlying diseases were identified only in 60 (35.29%) patients, of which 26 (15.29%) were severely immunocompromised, and 26 (15.29%) others were mildly immunocompromised. A statistically significant difference was reported for chronic renal failure, and anemia (p < 0.05) persisted in cases of three infection types. A high number of non-wild type (NWT) isolates were found against amphotericin B (n=13/145, 8.96%), followed by itraconazole (n=7/136, 5.15%) and voriconazole (n=4/158, 2.53%). Only six isolates (3.79%) were multidrug-resistant, four of which were from cryptococcemia patients. Compared to meningitis and pneumonia, cryptococcemia revealed a higher percentage of NWT isolates (p < 0.05). CONCLUSION: In high-risk populations, cryptococcal infections require ongoing monitoring and management. Dove 2023-07-06 /pmc/articles/PMC10332366/ /pubmed/37435235 http://dx.doi.org/10.2147/IDR.S417968 Text en © 2023 Bilal et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Bilal, Hazrat Zhang, Dongxing Shafiq, Muhammad Khan, Muhammad Nadeem Chen, Canhua Khan, Sabir Wang, Qian Cai, Lin Awais, Muhammad Hu, Haibin Zeng, Yuebin Cryptococcosis in Southern China: Insights from a Six-Year Retrospective Study in Eastern Guangdong |
title | Cryptococcosis in Southern China: Insights from a Six-Year Retrospective Study in Eastern Guangdong |
title_full | Cryptococcosis in Southern China: Insights from a Six-Year Retrospective Study in Eastern Guangdong |
title_fullStr | Cryptococcosis in Southern China: Insights from a Six-Year Retrospective Study in Eastern Guangdong |
title_full_unstemmed | Cryptococcosis in Southern China: Insights from a Six-Year Retrospective Study in Eastern Guangdong |
title_short | Cryptococcosis in Southern China: Insights from a Six-Year Retrospective Study in Eastern Guangdong |
title_sort | cryptococcosis in southern china: insights from a six-year retrospective study in eastern guangdong |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332366/ https://www.ncbi.nlm.nih.gov/pubmed/37435235 http://dx.doi.org/10.2147/IDR.S417968 |
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