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The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome

Evidence suggests that inhibition of α/β hydrolase-domain containing 6 (ABHD6) reduces seizures; however, the molecular mechanism of this therapeutic response remains unknown. We discovered that heterozygous expression of Abhd6 (Abhd6(+/−)) significantly reduced the premature lethality of Scn1a(+/−)...

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Detalles Bibliográficos
Autores principales:	Westenbroek, Ruth, Kaplan, Joshua, Viray, Katie, Stella, Nephi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332637/ https://www.ncbi.nlm.nih.gov/pubmed/36990366 http://dx.doi.org/10.1016/j.nbd.2023.106099

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