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Primary Effusion Lymphoma-like ATL Developing during Hemodialysis

We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along...

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Autores principales: Masaki, Miharu, Okushi, Yuki, Saito, Atsushi, Fukuda, Akihiro, Yamada, Sohsuke, Mizuta, Shuichi, Masaki, Yasufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332963/
https://www.ncbi.nlm.nih.gov/pubmed/36261387
http://dx.doi.org/10.2169/internalmedicine.9745-22
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author Masaki, Miharu
Okushi, Yuki
Saito, Atsushi
Fukuda, Akihiro
Yamada, Sohsuke
Mizuta, Shuichi
Masaki, Yasufumi
author_facet Masaki, Miharu
Okushi, Yuki
Saito, Atsushi
Fukuda, Akihiro
Yamada, Sohsuke
Mizuta, Shuichi
Masaki, Yasufumi
author_sort Masaki, Miharu
collection PubMed
description We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted.
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spelling pubmed-103329632023-07-12 Primary Effusion Lymphoma-like ATL Developing during Hemodialysis Masaki, Miharu Okushi, Yuki Saito, Atsushi Fukuda, Akihiro Yamada, Sohsuke Mizuta, Shuichi Masaki, Yasufumi Intern Med Case Report We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted. The Japanese Society of Internal Medicine 2022-10-19 2023-06-15 /pmc/articles/PMC10332963/ /pubmed/36261387 http://dx.doi.org/10.2169/internalmedicine.9745-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Masaki, Miharu
Okushi, Yuki
Saito, Atsushi
Fukuda, Akihiro
Yamada, Sohsuke
Mizuta, Shuichi
Masaki, Yasufumi
Primary Effusion Lymphoma-like ATL Developing during Hemodialysis
title Primary Effusion Lymphoma-like ATL Developing during Hemodialysis
title_full Primary Effusion Lymphoma-like ATL Developing during Hemodialysis
title_fullStr Primary Effusion Lymphoma-like ATL Developing during Hemodialysis
title_full_unstemmed Primary Effusion Lymphoma-like ATL Developing during Hemodialysis
title_short Primary Effusion Lymphoma-like ATL Developing during Hemodialysis
title_sort primary effusion lymphoma-like atl developing during hemodialysis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332963/
https://www.ncbi.nlm.nih.gov/pubmed/36261387
http://dx.doi.org/10.2169/internalmedicine.9745-22
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