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Primary Effusion Lymphoma-like ATL Developing during Hemodialysis
We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332963/ https://www.ncbi.nlm.nih.gov/pubmed/36261387 http://dx.doi.org/10.2169/internalmedicine.9745-22 |
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author | Masaki, Miharu Okushi, Yuki Saito, Atsushi Fukuda, Akihiro Yamada, Sohsuke Mizuta, Shuichi Masaki, Yasufumi |
author_facet | Masaki, Miharu Okushi, Yuki Saito, Atsushi Fukuda, Akihiro Yamada, Sohsuke Mizuta, Shuichi Masaki, Yasufumi |
author_sort | Masaki, Miharu |
collection | PubMed |
description | We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted. |
format | Online Article Text |
id | pubmed-10332963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-103329632023-07-12 Primary Effusion Lymphoma-like ATL Developing during Hemodialysis Masaki, Miharu Okushi, Yuki Saito, Atsushi Fukuda, Akihiro Yamada, Sohsuke Mizuta, Shuichi Masaki, Yasufumi Intern Med Case Report We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted. The Japanese Society of Internal Medicine 2022-10-19 2023-06-15 /pmc/articles/PMC10332963/ /pubmed/36261387 http://dx.doi.org/10.2169/internalmedicine.9745-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Masaki, Miharu Okushi, Yuki Saito, Atsushi Fukuda, Akihiro Yamada, Sohsuke Mizuta, Shuichi Masaki, Yasufumi Primary Effusion Lymphoma-like ATL Developing during Hemodialysis |
title | Primary Effusion Lymphoma-like ATL Developing during Hemodialysis |
title_full | Primary Effusion Lymphoma-like ATL Developing during Hemodialysis |
title_fullStr | Primary Effusion Lymphoma-like ATL Developing during Hemodialysis |
title_full_unstemmed | Primary Effusion Lymphoma-like ATL Developing during Hemodialysis |
title_short | Primary Effusion Lymphoma-like ATL Developing during Hemodialysis |
title_sort | primary effusion lymphoma-like atl developing during hemodialysis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332963/ https://www.ncbi.nlm.nih.gov/pubmed/36261387 http://dx.doi.org/10.2169/internalmedicine.9745-22 |
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