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Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review
We encountered a 78-year-old Japanese man with IgG4-related sialoadenitis complicated with marked eosinophilia. We diagnosed him with IgG4-RD (related disease) with a submandibular gland tumor, serum IgG4 elevation, IgG4-positive plasma cell infiltration, and storiform fibrosis. During follow-up aft...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Japanese Society of Internal Medicine
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332968/ https://www.ncbi.nlm.nih.gov/pubmed/36351576 http://dx.doi.org/10.2169/internalmedicine.0453-22 |
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| author | Origuchi, Tomoki Uchida, Tomohisa Sakaguchi, Tatsuki Matsuo, Haruna Michitsuji, Toru Umeda, Masataka Shimizu, Toshimasa Koga, Tomohiro Kawashiri, Shin-Ya Iwamoto, Naoki Ichinose, Kunihiro Tamai, Mami Ichinose, Masahiro Ando, Koji Horie, Ichiro Nakao, Nobuhiro Irie, Junji Kawakami, Atsushi |
| author_facet | Origuchi, Tomoki Uchida, Tomohisa Sakaguchi, Tatsuki Matsuo, Haruna Michitsuji, Toru Umeda, Masataka Shimizu, Toshimasa Koga, Tomohiro Kawashiri, Shin-Ya Iwamoto, Naoki Ichinose, Kunihiro Tamai, Mami Ichinose, Masahiro Ando, Koji Horie, Ichiro Nakao, Nobuhiro Irie, Junji Kawakami, Atsushi |
| author_sort | Origuchi, Tomoki |
| collection | PubMed |
| description | We encountered a 78-year-old Japanese man with IgG4-related sialoadenitis complicated with marked eosinophilia. We diagnosed him with IgG4-RD (related disease) with a submandibular gland tumor, serum IgG4 elevation, IgG4-positive plasma cell infiltration, and storiform fibrosis. During follow-up after total incision of the submandibular gland, the peripheral eosinophil count was markedly elevated to 29,480 /μL. The differential diagnosis of severe eosinophilia without IgG4-RD was excluded. The patient exhibited a prompt response to corticosteroid therapy. His peripheral blood eosinophil count was the highest ever reported among similar cases. We also review previous cases of IgG4-RD with severe eosinophilia. |
| format | Online Article Text |
| id | pubmed-10332968 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | The Japanese Society of Internal Medicine |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103329682023-07-12 Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review Origuchi, Tomoki Uchida, Tomohisa Sakaguchi, Tatsuki Matsuo, Haruna Michitsuji, Toru Umeda, Masataka Shimizu, Toshimasa Koga, Tomohiro Kawashiri, Shin-Ya Iwamoto, Naoki Ichinose, Kunihiro Tamai, Mami Ichinose, Masahiro Ando, Koji Horie, Ichiro Nakao, Nobuhiro Irie, Junji Kawakami, Atsushi Intern Med Case Report We encountered a 78-year-old Japanese man with IgG4-related sialoadenitis complicated with marked eosinophilia. We diagnosed him with IgG4-RD (related disease) with a submandibular gland tumor, serum IgG4 elevation, IgG4-positive plasma cell infiltration, and storiform fibrosis. During follow-up after total incision of the submandibular gland, the peripheral eosinophil count was markedly elevated to 29,480 /μL. The differential diagnosis of severe eosinophilia without IgG4-RD was excluded. The patient exhibited a prompt response to corticosteroid therapy. His peripheral blood eosinophil count was the highest ever reported among similar cases. We also review previous cases of IgG4-RD with severe eosinophilia. The Japanese Society of Internal Medicine 2022-11-09 2023-06-15 /pmc/articles/PMC10332968/ /pubmed/36351576 http://dx.doi.org/10.2169/internalmedicine.0453-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Case Report Origuchi, Tomoki Uchida, Tomohisa Sakaguchi, Tatsuki Matsuo, Haruna Michitsuji, Toru Umeda, Masataka Shimizu, Toshimasa Koga, Tomohiro Kawashiri, Shin-Ya Iwamoto, Naoki Ichinose, Kunihiro Tamai, Mami Ichinose, Masahiro Ando, Koji Horie, Ichiro Nakao, Nobuhiro Irie, Junji Kawakami, Atsushi Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review |
| title | Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review |
| title_full | Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review |
| title_fullStr | Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review |
| title_full_unstemmed | Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review |
| title_short | Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review |
| title_sort | immunoglobulin g4-related disease with marked eosinophilia: a case report and literature review |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332968/ https://www.ncbi.nlm.nih.gov/pubmed/36351576 http://dx.doi.org/10.2169/internalmedicine.0453-22 |
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