Intraprocedural Thrombotic Events during Percutaneous Coronary Intervention Due to Acquired Antithrombin Deficiency-related Heparin Resistance Successfully Treated with Antithrombin Gamma Supplementation

A 75-year-old man receiving treatment for necrotizing pancreatitis developed septic disseminated intravascular coagulation and acute coronary syndrome (ACS). During percutaneous coronary intervention (PCI), a large amount of fresh thrombi appeared after balloon dilatation for the ACS-culprit lesion....

Descripción completa

Detalles Bibliográficos
Autores principales: Yokoi, Masashi, Ito, Tsuyoshi, Yamamoto, Junki, Mori, Kento, Nakasuka, Kosuke, Fujita, Hiroshi, Kitada, Shuichi, Goto, Toshihiko, Seo, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332976/
https://www.ncbi.nlm.nih.gov/pubmed/36351584
http://dx.doi.org/10.2169/internalmedicine.0720-22
_version_ 1785070553070043136
author Yokoi, Masashi
Ito, Tsuyoshi
Yamamoto, Junki
Mori, Kento
Nakasuka, Kosuke
Fujita, Hiroshi
Kitada, Shuichi
Goto, Toshihiko
Seo, Yoshihiro
author_facet Yokoi, Masashi
Ito, Tsuyoshi
Yamamoto, Junki
Mori, Kento
Nakasuka, Kosuke
Fujita, Hiroshi
Kitada, Shuichi
Goto, Toshihiko
Seo, Yoshihiro
author_sort Yokoi, Masashi
collection PubMed
description A 75-year-old man receiving treatment for necrotizing pancreatitis developed septic disseminated intravascular coagulation and acute coronary syndrome (ACS). During percutaneous coronary intervention (PCI), a large amount of fresh thrombi appeared after balloon dilatation for the ACS-culprit lesion. Given the low plasma antithrombin (AT) activity and poorly prolonged activated clotting time (ACT), we suspected that acquired AT deficiency-related heparin resistance (HR) was responsible for the thrombus formation. Administration of AT gamma markedly improved ACT, and we successfully completed PCI. We suggest that AT gamma be considered a treatment option for AT deficiency-related HR and subsequent intraprocedural thrombotic events.
format Online
Article
Text
id pubmed-10332976
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-103329762023-07-12 Intraprocedural Thrombotic Events during Percutaneous Coronary Intervention Due to Acquired Antithrombin Deficiency-related Heparin Resistance Successfully Treated with Antithrombin Gamma Supplementation Yokoi, Masashi Ito, Tsuyoshi Yamamoto, Junki Mori, Kento Nakasuka, Kosuke Fujita, Hiroshi Kitada, Shuichi Goto, Toshihiko Seo, Yoshihiro Intern Med Case Report A 75-year-old man receiving treatment for necrotizing pancreatitis developed septic disseminated intravascular coagulation and acute coronary syndrome (ACS). During percutaneous coronary intervention (PCI), a large amount of fresh thrombi appeared after balloon dilatation for the ACS-culprit lesion. Given the low plasma antithrombin (AT) activity and poorly prolonged activated clotting time (ACT), we suspected that acquired AT deficiency-related heparin resistance (HR) was responsible for the thrombus formation. Administration of AT gamma markedly improved ACT, and we successfully completed PCI. We suggest that AT gamma be considered a treatment option for AT deficiency-related HR and subsequent intraprocedural thrombotic events. The Japanese Society of Internal Medicine 2022-11-09 2023-06-15 /pmc/articles/PMC10332976/ /pubmed/36351584 http://dx.doi.org/10.2169/internalmedicine.0720-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yokoi, Masashi
Ito, Tsuyoshi
Yamamoto, Junki
Mori, Kento
Nakasuka, Kosuke
Fujita, Hiroshi
Kitada, Shuichi
Goto, Toshihiko
Seo, Yoshihiro
Intraprocedural Thrombotic Events during Percutaneous Coronary Intervention Due to Acquired Antithrombin Deficiency-related Heparin Resistance Successfully Treated with Antithrombin Gamma Supplementation
title Intraprocedural Thrombotic Events during Percutaneous Coronary Intervention Due to Acquired Antithrombin Deficiency-related Heparin Resistance Successfully Treated with Antithrombin Gamma Supplementation
title_full Intraprocedural Thrombotic Events during Percutaneous Coronary Intervention Due to Acquired Antithrombin Deficiency-related Heparin Resistance Successfully Treated with Antithrombin Gamma Supplementation
title_fullStr Intraprocedural Thrombotic Events during Percutaneous Coronary Intervention Due to Acquired Antithrombin Deficiency-related Heparin Resistance Successfully Treated with Antithrombin Gamma Supplementation
title_full_unstemmed Intraprocedural Thrombotic Events during Percutaneous Coronary Intervention Due to Acquired Antithrombin Deficiency-related Heparin Resistance Successfully Treated with Antithrombin Gamma Supplementation
title_short Intraprocedural Thrombotic Events during Percutaneous Coronary Intervention Due to Acquired Antithrombin Deficiency-related Heparin Resistance Successfully Treated with Antithrombin Gamma Supplementation
title_sort intraprocedural thrombotic events during percutaneous coronary intervention due to acquired antithrombin deficiency-related heparin resistance successfully treated with antithrombin gamma supplementation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332976/
https://www.ncbi.nlm.nih.gov/pubmed/36351584
http://dx.doi.org/10.2169/internalmedicine.0720-22
work_keys_str_mv AT yokoimasashi intraproceduralthromboticeventsduringpercutaneouscoronaryinterventionduetoacquiredantithrombindeficiencyrelatedheparinresistancesuccessfullytreatedwithantithrombingammasupplementation
AT itotsuyoshi intraproceduralthromboticeventsduringpercutaneouscoronaryinterventionduetoacquiredantithrombindeficiencyrelatedheparinresistancesuccessfullytreatedwithantithrombingammasupplementation
AT yamamotojunki intraproceduralthromboticeventsduringpercutaneouscoronaryinterventionduetoacquiredantithrombindeficiencyrelatedheparinresistancesuccessfullytreatedwithantithrombingammasupplementation
AT morikento intraproceduralthromboticeventsduringpercutaneouscoronaryinterventionduetoacquiredantithrombindeficiencyrelatedheparinresistancesuccessfullytreatedwithantithrombingammasupplementation
AT nakasukakosuke intraproceduralthromboticeventsduringpercutaneouscoronaryinterventionduetoacquiredantithrombindeficiencyrelatedheparinresistancesuccessfullytreatedwithantithrombingammasupplementation
AT fujitahiroshi intraproceduralthromboticeventsduringpercutaneouscoronaryinterventionduetoacquiredantithrombindeficiencyrelatedheparinresistancesuccessfullytreatedwithantithrombingammasupplementation
AT kitadashuichi intraproceduralthromboticeventsduringpercutaneouscoronaryinterventionduetoacquiredantithrombindeficiencyrelatedheparinresistancesuccessfullytreatedwithantithrombingammasupplementation
AT gototoshihiko intraproceduralthromboticeventsduringpercutaneouscoronaryinterventionduetoacquiredantithrombindeficiencyrelatedheparinresistancesuccessfullytreatedwithantithrombingammasupplementation
AT seoyoshihiro intraproceduralthromboticeventsduringpercutaneouscoronaryinterventionduetoacquiredantithrombindeficiencyrelatedheparinresistancesuccessfullytreatedwithantithrombingammasupplementation

Ejemplares similares