Focal Segmental Glomerulosclerosis Associated with Essential Thrombocythemia

A 72-year-old man was admitted for examination of proteinuria (9.14 g/day) and leg edema. Essential thrombocythemia (ET) was diagnosed because of thrombocytosis (platelet count, 57.9×10(4)/μL), elevated megakaryocytes in bone marrow biopsy, and JAK2 V617 mutation. Kidney biopsy led to a diagnosis of...

Descripción completa

Detalles Bibliográficos
Autores principales: Sugimoto, Hisashi, Sawa, Naoki, Yamagiwa, Hajime, Kawada, Masahiro, Ikuma, Daisuke, Oba, Yuki, Mizuno, Hiroki, Sekine, Akinari, Yamanouchi, Masayuki, Hasegawa, Eiko, Suwabe, Tatsuya, Nishida, Aya, Kono, Kei, Kinowaki, Keiichi, Ohashi, Kenichi, Yamaguchi, Yutaka, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332981/
https://www.ncbi.nlm.nih.gov/pubmed/36288989
http://dx.doi.org/10.2169/internalmedicine.0767-22
Descripción
Sumario:A 72-year-old man was admitted for examination of proteinuria (9.14 g/day) and leg edema. Essential thrombocythemia (ET) was diagnosed because of thrombocytosis (platelet count, 57.9×10(4)/μL), elevated megakaryocytes in bone marrow biopsy, and JAK2 V617 mutation. Kidney biopsy led to a diagnosis of focal segmental glomerulosclerosis (FSGS) cellular variant (characterized by glomerular capillaries filled with swollen endothelial cells containing foam cells) in 6 glomeruli, FSGS tip variant in 5 glomeruli, and additional FSGS variants in other glomeruli. Affected glomeruli had anti-CD61 antibody staining-positive megakaryocyte infiltrations. ET may induce FSGS because megakaryocyte infiltration increases intraglomerular pressure, resulting in hypertension and proteinuria.

Ejemplares similares