Two Cases of Encephalitis without Anti-N-methyl-D-aspartate Receptor Antibody Successfully Treated with Ovarian Teratoma Resection and Immunotherapy

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder sometimes accompanied by ovarian teratoma. However, the concept of encephalitis without anti-NMDAR antibodies successfully treated with ovarian teratoma resection and immunotherapy has not been established. We herein r...

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Detalles Bibliográficos
Autores principales: Morooka, Marie, Hiraga, Akiyuki, Tanaka, Keiko, Yoshizaki, Satoko, Koide, Kyosuke, Kuwabara, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332985/
https://www.ncbi.nlm.nih.gov/pubmed/36328575
http://dx.doi.org/10.2169/internalmedicine.0447-22
Descripción
Sumario:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder sometimes accompanied by ovarian teratoma. However, the concept of encephalitis without anti-NMDAR antibodies successfully treated with ovarian teratoma resection and immunotherapy has not been established. We herein report two such cases. Case 1 exhibited delayed magnetic resonance imaging abnormalities in the thalamus and basal ganglia, despite clinical improvement. Case 2 presented with brainstem encephalitis similar to Bickerstaff's encephalitis. Although both patients tested negative for anti-NMDAR antibodies, the recovery of the neurological function and good prognosis following tumor resection with immunotherapy indicated a close association between these diseases and ovarian teratoma.

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