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The use of epidermal growth factor in dermatological practice

Epidermal growth factor (EGF) is a growth factor that plays a pivotal role in wound healing and maintaining tissue homeostasis by regulating cell survival, proliferation, migration, and differentiation. Exogenous administration of bioidentical human recombinant epidermal growth factor (rhEGF) has be...

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Autores principales: Shin, Sun Hye, Koh, Young Gue, Lee, Woo Geon, Seok, Joon, Park, Kui Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333026/
https://www.ncbi.nlm.nih.gov/pubmed/36584669
http://dx.doi.org/10.1111/iwj.14075
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author Shin, Sun Hye
Koh, Young Gue
Lee, Woo Geon
Seok, Joon
Park, Kui Young
author_facet Shin, Sun Hye
Koh, Young Gue
Lee, Woo Geon
Seok, Joon
Park, Kui Young
author_sort Shin, Sun Hye
collection PubMed
description Epidermal growth factor (EGF) is a growth factor that plays a pivotal role in wound healing and maintaining tissue homeostasis by regulating cell survival, proliferation, migration, and differentiation. Exogenous administration of bioidentical human recombinant epidermal growth factor (rhEGF) has been known to promote skin wound healing, although rhEGF is increasingly being used in drug delivery systems and nanotechnology. However, despite considerable attention being focused on the potential clinical applications of rhEGF in several dermatological conditions beyond wound healing, the number of studies still remains relatively low. Herein, we conducted a literature search of PubMed/Medline and Google Scholar databases to retrieve published literature related to rhEGF and summarised the effects of rhEGF in the treatment of various wound types, radiotherapy or chemotherapy‐related skin reactions, atopic dermatitis, skin aging, and post‐inflammatory hyperpigmentation.
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spelling pubmed-103330262023-07-12 The use of epidermal growth factor in dermatological practice Shin, Sun Hye Koh, Young Gue Lee, Woo Geon Seok, Joon Park, Kui Young Int Wound J Review Articles Epidermal growth factor (EGF) is a growth factor that plays a pivotal role in wound healing and maintaining tissue homeostasis by regulating cell survival, proliferation, migration, and differentiation. Exogenous administration of bioidentical human recombinant epidermal growth factor (rhEGF) has been known to promote skin wound healing, although rhEGF is increasingly being used in drug delivery systems and nanotechnology. However, despite considerable attention being focused on the potential clinical applications of rhEGF in several dermatological conditions beyond wound healing, the number of studies still remains relatively low. Herein, we conducted a literature search of PubMed/Medline and Google Scholar databases to retrieve published literature related to rhEGF and summarised the effects of rhEGF in the treatment of various wound types, radiotherapy or chemotherapy‐related skin reactions, atopic dermatitis, skin aging, and post‐inflammatory hyperpigmentation. Blackwell Publishing Ltd 2022-12-30 /pmc/articles/PMC10333026/ /pubmed/36584669 http://dx.doi.org/10.1111/iwj.14075 Text en © 2022 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Shin, Sun Hye
Koh, Young Gue
Lee, Woo Geon
Seok, Joon
Park, Kui Young
The use of epidermal growth factor in dermatological practice
title The use of epidermal growth factor in dermatological practice
title_full The use of epidermal growth factor in dermatological practice
title_fullStr The use of epidermal growth factor in dermatological practice
title_full_unstemmed The use of epidermal growth factor in dermatological practice
title_short The use of epidermal growth factor in dermatological practice
title_sort use of epidermal growth factor in dermatological practice
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333026/
https://www.ncbi.nlm.nih.gov/pubmed/36584669
http://dx.doi.org/10.1111/iwj.14075
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