Fabrication of baicalein‐encapsulated zeolitic imidazole framework as a novel nanocomposited wound closure material to persuade pH‐responsive healing efficacy in post‐caesarean section wound care

Baicalein is a plant‐derived compound, it has widespread attention among biomedical researchers due to its biocompatibility and efficient biological activities. But it has non‐solubility in physiological conditions and short bioavailability in the clinical process. The Discovery of a stimuli‐based drug delivery system (DDS) is a perfect strategy to improve the bioactivity of baicalin in post‐caesarean section wound care. We prepared a baicalein‐encapsulated pH‐responsive DDS with a zeolite imidazole framework‐8 (ZIF‐8) as a carrier. We investigated the material characteristics of DDS in terms of crystal structure, surface area morphology, particle size, FTIR, UV–vis, Powder XRD, and BET analysis techniques. The in vitro cytotoxicity, biocompatibility, and cell proliferation properties of BA@ZIF‐8 were assessed against human fibroblast L929 cells. In vitro studies showed that BA@ZIF‐8 nanocomposite significantly enhanced the biocompatibility against L929 cells after 72 h post‐exposure. The pH‐responsive drug release kinetics shows excellent baicalein release under acidic conditions and without unwanted drug release in physiological conditions. Wound scratch assay results revealed, that BA@ZIF‐8 nanocomposite‐treated cells exhibit the fastest cell proliferation and migration process in a very short period. In the antibacterial activity study, nanocomposite exposed dose depended on inhibition against wound infectious pathogens. The overall study signifies that BA@ZIF‐8 nano‐DDSs are effective and suitable DDS for stimuli‐based post‐caesarean section wound care.