Cargando…

Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways

Swertia cincta Burkill is widely distributed along the southwestern region of China. It is known as “Dida” in Tibetan and “Qingyedan” in Chinese medicine. It was used in folk medicine to treat hepatitis and other liver diseases. To understand how Swertia cincta Burkill extract (ESC) protects against...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xinyan, Zheng, Xiaomei, Wen, Qiqi, Zhang, Yang, Tang, Huaqiao, Zhao, Ling, Shi, Fei, Li, Yinglun, Yin, Zhongqiong, Zou, Yuanfeng, Song, Xu, Li, Lixia, Zhao, Xinghong, Ye, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333062/
https://www.ncbi.nlm.nih.gov/pubmed/37379130
http://dx.doi.org/10.18632/aging.204848
_version_ 1785070573626327040
author Wu, Xinyan
Zheng, Xiaomei
Wen, Qiqi
Zhang, Yang
Tang, Huaqiao
Zhao, Ling
Shi, Fei
Li, Yinglun
Yin, Zhongqiong
Zou, Yuanfeng
Song, Xu
Li, Lixia
Zhao, Xinghong
Ye, Gang
author_facet Wu, Xinyan
Zheng, Xiaomei
Wen, Qiqi
Zhang, Yang
Tang, Huaqiao
Zhao, Ling
Shi, Fei
Li, Yinglun
Yin, Zhongqiong
Zou, Yuanfeng
Song, Xu
Li, Lixia
Zhao, Xinghong
Ye, Gang
author_sort Wu, Xinyan
collection PubMed
description Swertia cincta Burkill is widely distributed along the southwestern region of China. It is known as “Dida” in Tibetan and “Qingyedan” in Chinese medicine. It was used in folk medicine to treat hepatitis and other liver diseases. To understand how Swertia cincta Burkill extract (ESC) protects against acute liver failure (ALF), firstly, the active ingredients of ESC were identified using liquid chromatography-mass spectrometry (LC-MS), and further screening. Next, network pharmacology analyses were performed to identify the core targets of ESC against ALF and further determine the potential mechanisms. Finally, in vivo experiments as well as in vitro experiments were conducted for further validation. The results revealed that 72 potential targets of ESC were identified using target prediction. The core targets were ALB, ERBB2, AKT1, MMP9, EGFR, PTPRC, MTOR, ESR1, VEGFA, and HIF1A. Next, KEGG pathway analysis showed that EGFR and PI3K-AKT signaling pathways could have been involved in ESC against ALF. ESC exhibits hepatic protective functions via anti-inflammatory, antioxidant, and anti-apoptotic effects. Therefore, the EGFR-ERK, PI3K-AKT, and NRF2/HO-1 signaling pathways could participate in the therapeutic effects of ESC on ALF.
format Online
Article
Text
id pubmed-10333062
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Impact Journals
record_format MEDLINE/PubMed
spelling pubmed-103330622023-07-12 Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways Wu, Xinyan Zheng, Xiaomei Wen, Qiqi Zhang, Yang Tang, Huaqiao Zhao, Ling Shi, Fei Li, Yinglun Yin, Zhongqiong Zou, Yuanfeng Song, Xu Li, Lixia Zhao, Xinghong Ye, Gang Aging (Albany NY) Research Paper Swertia cincta Burkill is widely distributed along the southwestern region of China. It is known as “Dida” in Tibetan and “Qingyedan” in Chinese medicine. It was used in folk medicine to treat hepatitis and other liver diseases. To understand how Swertia cincta Burkill extract (ESC) protects against acute liver failure (ALF), firstly, the active ingredients of ESC were identified using liquid chromatography-mass spectrometry (LC-MS), and further screening. Next, network pharmacology analyses were performed to identify the core targets of ESC against ALF and further determine the potential mechanisms. Finally, in vivo experiments as well as in vitro experiments were conducted for further validation. The results revealed that 72 potential targets of ESC were identified using target prediction. The core targets were ALB, ERBB2, AKT1, MMP9, EGFR, PTPRC, MTOR, ESR1, VEGFA, and HIF1A. Next, KEGG pathway analysis showed that EGFR and PI3K-AKT signaling pathways could have been involved in ESC against ALF. ESC exhibits hepatic protective functions via anti-inflammatory, antioxidant, and anti-apoptotic effects. Therefore, the EGFR-ERK, PI3K-AKT, and NRF2/HO-1 signaling pathways could participate in the therapeutic effects of ESC on ALF. Impact Journals 2023-06-27 /pmc/articles/PMC10333062/ /pubmed/37379130 http://dx.doi.org/10.18632/aging.204848 Text en Copyright: © 2023 Wu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wu, Xinyan
Zheng, Xiaomei
Wen, Qiqi
Zhang, Yang
Tang, Huaqiao
Zhao, Ling
Shi, Fei
Li, Yinglun
Yin, Zhongqiong
Zou, Yuanfeng
Song, Xu
Li, Lixia
Zhao, Xinghong
Ye, Gang
Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways
title Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways
title_full Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways
title_fullStr Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways
title_full_unstemmed Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways
title_short Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways
title_sort swertia cincta burkill alleviates lps/d-galn-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333062/
https://www.ncbi.nlm.nih.gov/pubmed/37379130
http://dx.doi.org/10.18632/aging.204848
work_keys_str_mv AT wuxinyan swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT zhengxiaomei swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT wenqiqi swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT zhangyang swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT tanghuaqiao swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT zhaoling swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT shifei swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT liyinglun swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT yinzhongqiong swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT zouyuanfeng swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT songxu swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT lilixia swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT zhaoxinghong swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways
AT yegang swertiacinctaburkillalleviateslpsdgalninducedacuteliverfailurebymodulatingapoptosisandoxidativestresssignalingpathways