Astaxanthin prevents osteoarthritis by blocking Rspo2-mediated Wnt/β-catenin signaling in chondrocytes and abolishing Rspo2-related inflammatory factors in macrophages

Chondrocyte degeneration and classically activated macrophage (AM)-related inflammation play critical roles in osteoarthritis (OA). Here, we explored the effects of astaxanthin and Rspo2 on OA in vitro and in vivo. We observed that the Rspo2 gene was markedly elevated in synovial tissues of OA patie...

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Detalles Bibliográficos
Autores principales: Zhu, Chunhui, Liu, Gang, Cui, Weiding, Yu, Zhongjie, Chen, Wei, Qin, Yao, Liu, Jiuxiang, Lu, Yaojun, Fan, Weimin, Liang, Wenwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333078/
https://www.ncbi.nlm.nih.gov/pubmed/37354487
http://dx.doi.org/10.18632/aging.204837

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