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Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation

Diabetes mellitus (DM) is a metabolic disease that affects all systems in the body, including the liver. Numerous studies have reported that chronic DM etiology and pathogenesis complications implicate oxidative stress, generating reactive oxygen species, such as superoxide anions and free radicals....

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Autores principales: Bae, Chun-Sik, Lee, Youngchan, Ahn, Taeho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333167/
https://www.ncbi.nlm.nih.gov/pubmed/37428327
http://dx.doi.org/10.1186/s42649-023-00089-2
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author Bae, Chun-Sik
Lee, Youngchan
Ahn, Taeho
author_facet Bae, Chun-Sik
Lee, Youngchan
Ahn, Taeho
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description Diabetes mellitus (DM) is a metabolic disease that affects all systems in the body, including the liver. Numerous studies have reported that chronic DM etiology and pathogenesis complications implicate oxidative stress, generating reactive oxygen species, such as superoxide anions and free radicals. In addition, pro-inflammatory reactions are also underlying functions closely related to oxidative stress that further exacerbate pathological DM states. The liver is especially susceptible to hyperglycemia-induced oxidative stress and the related inflammation. Thus, anti-oxidation and anti-inflammation therapies are promising strategies for treating liver damage. This review summarizes therapeutic treatments attenuating the generation of oxidative stress and pro-inflammation, which also cause DM-induced liver injury. Although the treatments have several impediments to be solved, these remedies may have clinically important implications under the absence of effective drugs for the damaged liver in DM patients.
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spelling pubmed-103331672023-07-12 Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation Bae, Chun-Sik Lee, Youngchan Ahn, Taeho Appl Microsc Review Diabetes mellitus (DM) is a metabolic disease that affects all systems in the body, including the liver. Numerous studies have reported that chronic DM etiology and pathogenesis complications implicate oxidative stress, generating reactive oxygen species, such as superoxide anions and free radicals. In addition, pro-inflammatory reactions are also underlying functions closely related to oxidative stress that further exacerbate pathological DM states. The liver is especially susceptible to hyperglycemia-induced oxidative stress and the related inflammation. Thus, anti-oxidation and anti-inflammation therapies are promising strategies for treating liver damage. This review summarizes therapeutic treatments attenuating the generation of oxidative stress and pro-inflammation, which also cause DM-induced liver injury. Although the treatments have several impediments to be solved, these remedies may have clinically important implications under the absence of effective drugs for the damaged liver in DM patients. Springer Nature Singapore 2023-07-10 /pmc/articles/PMC10333167/ /pubmed/37428327 http://dx.doi.org/10.1186/s42649-023-00089-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Bae, Chun-Sik
Lee, Youngchan
Ahn, Taeho
Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation
title Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation
title_full Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation
title_fullStr Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation
title_full_unstemmed Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation
title_short Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation
title_sort therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333167/
https://www.ncbi.nlm.nih.gov/pubmed/37428327
http://dx.doi.org/10.1186/s42649-023-00089-2
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