Cargando…

ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression

Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) have been approved for both frontline and recurrent setting in ovarian cancer with homologous recombination (HR) repair deficiency. However, more than 40% of BRCA1/2-mutated ovarian cancer lack the initial response to PARPi treatment, and the ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lavudi, Kousalya, Banerjee, Ananya, Li, Na, Yang, Yajing, Cai, Shurui, Bai, Xuetao, Zhang, Xiaoli, Li, Aidan, Wani, Elsa, Yang, Shyh-Ming, Zhang, Junran, Rai, Ganesha, Backes, Floor, Patnaik, Srinivas, Guo, Peixuan, Wang, Qi-En
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333219/ https://www.ncbi.nlm.nih.gov/pubmed/37429899 http://dx.doi.org/10.1038/s41698-023-00411-x

Ejemplares similares

A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-to-Mesenchymal Transition
por: Banerjee, Ananya, et al.
Publicado: (2022)

Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers
por: Lavudi, Kousalya, et al.
Publicado: (2023)

ERK inactivation enhances stemness of NSCLC cells via promoting Slug-mediated epithelial-to-mesenchymal transition
por: Cai, Shurui, et al.
Publicado: (2022)

A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs
por: Goud, Vaggu Raghavendra, et al.
Publicado: (2022)

2-Dimensional in vitro culture assessment of ovarian cancer cell line using cost effective silver nanoparticles from Macrotyloma uniflorum seed extracts
por: Lavudi, Kousalya, et al.
Publicado: (2022)

Linking ALDH1 and retinoic acid signaling
por: Markham, Nicholas O., et al.
Publicado: (2019)

Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Swertia chirayita Leaf Extract on Colorectal Cancer Cells
por: Berehu, Hadgu Mendefro, et al.
Publicado: (2021)

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
por: Zatreanu, Diana, et al.
Publicado: (2021)

Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity
por: Barber, Casey N., et al.
Publicado: (2022)

Acute worsening of dermatomyositis after initiation of PARP inhibitor therapy in two women with advanced ovarian malignancy
por: Graves, Stephen M., et al.
Publicado: (2021)

On θ(ω) continuity
por: Al Ghour, Samer, et al.
Publicado: (2020)

Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary
por: Chassot, Anne-Amandine, et al.
Publicado: (2020)

Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity
por: Anel, Alberto, et al.
Publicado: (2012)

ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries
por: Bowles, Josephine, et al.
Publicado: (2016)

A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
por: Li, Jianfeng, et al.
Publicado: (2021)

PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling
por: Verma, Mamta, et al.
Publicado: (2021)

Cosϑ magnet design option
por: Lorin, C
Publicado: (2015)

Intervention of PKC-θ as an immunosuppressive regimen
por: Sun, Zuoming
Publicado: (2012)

Synthetic Lethality Targeting Polθ
por: Drzewiecka, Małgorzata, et al.
Publicado: (2022)

Multifaceted Nature of DNA Polymerase θ
por: Kruchinin, Alexander A., et al.
Publicado: (2023)

Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer
por: Biswas, Anup Kumar, et al.
Publicado: (2022)

DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1
por: Cui, Tiantian, et al.
Publicado: (2018)

Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70
por: Ding, Cui-Ling, et al.
Publicado: (2015)

Regulating the Regulator: Phosphorylation of PKC θ in T Cells
por: Freeley, Michael, et al.
Publicado: (2012)

The Novel PKCθ from Benchtop to Clinic
por: Hage-Sleiman, Rouba, et al.
Publicado: (2015)

DGK-θ: Structure, Enzymology, and Physiological Roles
por: Tu-Sekine, Becky, et al.
Publicado: (2016)

Consequences of Lineage-Specific Gene Loss on Functional Evolution of Surviving Paralogs: ALDH1A and Retinoic Acid Signaling in Vertebrate Genomes
por: Cañestro, Cristian, et al.
Publicado: (2009)

ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis
por: Weber, Thomas J., et al.
Publicado: (2014)

High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling
por: Kim, Donghyeok, et al.
Publicado: (2018)

PKCθ Signals Activation versus Tolerance In Vivo
por: Berg-Brown, Nancy N., et al.
Publicado: (2004)

Promiscuous DNA synthesis by human DNA polymerase θ
por: Hogg, Matthew, et al.
Publicado: (2012)

Discrete Symmetries and Neutrino Mass Perturbations for θ$_{13}$
por: Hall, L J, et al.
Publicado: (2013)

Precision measurements of mW and sin2θ
por: Vesterinen, Mika Anton
Publicado: (2022)

Polymerase θ inhibition steps on the cGAS pedal
por: Smith, Chelsea M., et al.
Publicado: (2023)

Transcriptome analysis and prognosis of ALDH isoforms in human cancer
por: Chang, Peter Mu-Hsin, et al.
Publicado: (2018)

In vitro analysis of PARP inhibitor nanoformulations
por: Baldwin, Paige, et al.
Publicado: (2018)

BRAIN AND THYMUS LIPID INHIBITION OF ANTIBRAIN-ASSOCIATED ϑ-CYTOTOXICITY
por: Esselman, W. J., et al.
Publicado: (1974)

Regulation of PKC-θ function by phosphorylation in T cell receptor signaling
por: Wang, Xiaohong, et al.
Publicado: (2012)

Precision measurements, W mass, sinθw (theory)
por: Freitas, Ayres
Publicado: (2021)

Electrical Resonance in the θ Frequency Range in Olfactory Amygdala Neurons
por: Vera, Jorge, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5ieo0uq9ekvgb8tq24b8bbfqaa