Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9

The CRISPR-Cas9 system has revolutionized our ability to precisely modify the genome and has led to gene editing in clinical applications. Comprehensive analysis of gene editing products at the targeted cut-site has revealed a complex spectrum of outcomes. ON-target genotoxicity is underestimated wi...

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Detalles Bibliográficos
Autores principales: Cullot, G., Boutin, J., Fayet, S., Prat, F., Rosier, J., Cappellen, D., Lamrissi, I., Pennamen, P., Bouron, J., Amintas, S., Thibault, C., Moranvillier, I., Laharanne, E., Merlio, J. P., Guyonnet-Duperat, V., Blouin, J. M., Richard, E., Dabernat, S., Moreau-Gaudry, F., Bedel, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333231/
https://www.ncbi.nlm.nih.gov/pubmed/37429857
http://dx.doi.org/10.1038/s41467-023-39632-w

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