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Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States
SARS-CoV-2 is a zoonotic virus with documented bi-directional transmission between people and animals. Transmission of SARS-CoV-2 from humans to free-ranging white-tailed deer (Odocoileus virginianus) poses a unique public health risk due to the potential for reservoir establishment where variants m...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333304/ https://www.ncbi.nlm.nih.gov/pubmed/37429851 http://dx.doi.org/10.1038/s41467-023-39782-x |
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author | Feng, Aijing Bevins, Sarah Chandler, Jeff DeLiberto, Thomas J. Ghai, Ria Lantz, Kristina Lenoch, Julianna Retchless, Adam Shriner, Susan Tang, Cynthia Y. Tong, Suxiang Sue Torchetti, Mia Uehara, Anna Wan, Xiu-Feng |
author_facet | Feng, Aijing Bevins, Sarah Chandler, Jeff DeLiberto, Thomas J. Ghai, Ria Lantz, Kristina Lenoch, Julianna Retchless, Adam Shriner, Susan Tang, Cynthia Y. Tong, Suxiang Sue Torchetti, Mia Uehara, Anna Wan, Xiu-Feng |
author_sort | Feng, Aijing |
collection | PubMed |
description | SARS-CoV-2 is a zoonotic virus with documented bi-directional transmission between people and animals. Transmission of SARS-CoV-2 from humans to free-ranging white-tailed deer (Odocoileus virginianus) poses a unique public health risk due to the potential for reservoir establishment where variants may persist and evolve. We collected 8,830 respiratory samples from free-ranging white-tailed deer across Washington, D.C. and 26 states in the United States between November 2021 and April 2022. We obtained 391 sequences and identified 34 Pango lineages including the Alpha, Gamma, Delta, and Omicron variants. Evolutionary analyses showed these white-tailed deer viruses originated from at least 109 independent spillovers from humans, which resulted in 39 cases of subsequent local deer-to-deer transmission and three cases of potential spillover from white-tailed deer back to humans. Viruses repeatedly adapted to white-tailed deer with recurring amino acid substitutions across spike and other proteins. Overall, our findings suggest that multiple SARS-CoV-2 lineages were introduced, became enzootic, and co-circulated in white-tailed deer. |
format | Online Article Text |
id | pubmed-10333304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103333042023-07-12 Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States Feng, Aijing Bevins, Sarah Chandler, Jeff DeLiberto, Thomas J. Ghai, Ria Lantz, Kristina Lenoch, Julianna Retchless, Adam Shriner, Susan Tang, Cynthia Y. Tong, Suxiang Sue Torchetti, Mia Uehara, Anna Wan, Xiu-Feng Nat Commun Article SARS-CoV-2 is a zoonotic virus with documented bi-directional transmission between people and animals. Transmission of SARS-CoV-2 from humans to free-ranging white-tailed deer (Odocoileus virginianus) poses a unique public health risk due to the potential for reservoir establishment where variants may persist and evolve. We collected 8,830 respiratory samples from free-ranging white-tailed deer across Washington, D.C. and 26 states in the United States between November 2021 and April 2022. We obtained 391 sequences and identified 34 Pango lineages including the Alpha, Gamma, Delta, and Omicron variants. Evolutionary analyses showed these white-tailed deer viruses originated from at least 109 independent spillovers from humans, which resulted in 39 cases of subsequent local deer-to-deer transmission and three cases of potential spillover from white-tailed deer back to humans. Viruses repeatedly adapted to white-tailed deer with recurring amino acid substitutions across spike and other proteins. Overall, our findings suggest that multiple SARS-CoV-2 lineages were introduced, became enzootic, and co-circulated in white-tailed deer. Nature Publishing Group UK 2023-07-10 /pmc/articles/PMC10333304/ /pubmed/37429851 http://dx.doi.org/10.1038/s41467-023-39782-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Feng, Aijing Bevins, Sarah Chandler, Jeff DeLiberto, Thomas J. Ghai, Ria Lantz, Kristina Lenoch, Julianna Retchless, Adam Shriner, Susan Tang, Cynthia Y. Tong, Suxiang Sue Torchetti, Mia Uehara, Anna Wan, Xiu-Feng Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States |
title | Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States |
title_full | Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States |
title_fullStr | Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States |
title_full_unstemmed | Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States |
title_short | Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States |
title_sort | transmission of sars-cov-2 in free-ranging white-tailed deer in the united states |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333304/ https://www.ncbi.nlm.nih.gov/pubmed/37429851 http://dx.doi.org/10.1038/s41467-023-39782-x |
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