Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization

Nearly 70% of Uterine fibroid (UF) tumors are driven by recurrent MED12 hotspot mutations. Unfortunately, no cellular models could be generated because the mutant cells have lower fitness in 2D culture conditions. To address this, we employ CRISPR to precisely engineer MED12 Gly44 mutations in UF-re...

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Detalles Bibliográficos
Autores principales: Buyukcelebi, Kadir, Chen, Xintong, Abdula, Fatih, Elkafas, Hoda, Duval, Alexander James, Ozturk, Harun, Seker-Polat, Fidan, Jin, Qiushi, Yin, Ping, Feng, Yue, Bulun, Serdar E., Wei, Jian Jun, Yue, Feng, Adli, Mazhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333368/
https://www.ncbi.nlm.nih.gov/pubmed/37429859
http://dx.doi.org/10.1038/s41467-023-39684-y

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