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Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential
Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection and spillover among them. We characterize the mammal-associated viruses in 149 individual ba...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333379/ https://www.ncbi.nlm.nih.gov/pubmed/37429936 http://dx.doi.org/10.1038/s41467-023-39835-1 |
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author | Wang, Jing Pan, Yuan-fei Yang, Li-fen Yang, Wei-hong Lv, Kexin Luo, Chu-ming Wang, Juan Kuang, Guo-peng Wu, Wei-chen Gou, Qin-yu Xin, Gen-yang Li, Bo Luo, Huan-le Chen, Shoudeng Shu, Yue-long Guo, Deyin Gao, Zi-Hou Liang, Guodong Li, Jun Chen, Yao-qing Holmes, Edward C. Feng, Yun Shi, Mang |
author_facet | Wang, Jing Pan, Yuan-fei Yang, Li-fen Yang, Wei-hong Lv, Kexin Luo, Chu-ming Wang, Juan Kuang, Guo-peng Wu, Wei-chen Gou, Qin-yu Xin, Gen-yang Li, Bo Luo, Huan-le Chen, Shoudeng Shu, Yue-long Guo, Deyin Gao, Zi-Hou Liang, Guodong Li, Jun Chen, Yao-qing Holmes, Edward C. Feng, Yun Shi, Mang |
author_sort | Wang, Jing |
collection | PubMed |
description | Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection and spillover among them. We characterize the mammal-associated viruses in 149 individual bats sampled from Yunnan province, China, using an unbiased meta-transcriptomics approach. This reveals a high frequency of virus co-infection (simultaneous infection of bat individuals by multiple viral species) and spillover among the animals studied, which may in turn facilitate virus recombination and reassortment. Of note, we identify five viral species that are likely to be pathogenic to humans or livestock, based on phylogenetic relatedness to known pathogens or in vitro receptor binding assays. This includes a novel recombinant SARS-like coronavirus that is closely related to both SARS-CoV and SARS-CoV-2. In vitro assays indicate that this recombinant virus can utilize the human ACE2 receptor such that it is likely to be of increased emergence risk. Our study highlights the common occurrence of co-infection and spillover of bat viruses and their implications for virus emergence. |
format | Online Article Text |
id | pubmed-10333379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103333792023-07-12 Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential Wang, Jing Pan, Yuan-fei Yang, Li-fen Yang, Wei-hong Lv, Kexin Luo, Chu-ming Wang, Juan Kuang, Guo-peng Wu, Wei-chen Gou, Qin-yu Xin, Gen-yang Li, Bo Luo, Huan-le Chen, Shoudeng Shu, Yue-long Guo, Deyin Gao, Zi-Hou Liang, Guodong Li, Jun Chen, Yao-qing Holmes, Edward C. Feng, Yun Shi, Mang Nat Commun Article Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection and spillover among them. We characterize the mammal-associated viruses in 149 individual bats sampled from Yunnan province, China, using an unbiased meta-transcriptomics approach. This reveals a high frequency of virus co-infection (simultaneous infection of bat individuals by multiple viral species) and spillover among the animals studied, which may in turn facilitate virus recombination and reassortment. Of note, we identify five viral species that are likely to be pathogenic to humans or livestock, based on phylogenetic relatedness to known pathogens or in vitro receptor binding assays. This includes a novel recombinant SARS-like coronavirus that is closely related to both SARS-CoV and SARS-CoV-2. In vitro assays indicate that this recombinant virus can utilize the human ACE2 receptor such that it is likely to be of increased emergence risk. Our study highlights the common occurrence of co-infection and spillover of bat viruses and their implications for virus emergence. Nature Publishing Group UK 2023-07-10 /pmc/articles/PMC10333379/ /pubmed/37429936 http://dx.doi.org/10.1038/s41467-023-39835-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wang, Jing Pan, Yuan-fei Yang, Li-fen Yang, Wei-hong Lv, Kexin Luo, Chu-ming Wang, Juan Kuang, Guo-peng Wu, Wei-chen Gou, Qin-yu Xin, Gen-yang Li, Bo Luo, Huan-le Chen, Shoudeng Shu, Yue-long Guo, Deyin Gao, Zi-Hou Liang, Guodong Li, Jun Chen, Yao-qing Holmes, Edward C. Feng, Yun Shi, Mang Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential |
title | Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential |
title_full | Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential |
title_fullStr | Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential |
title_full_unstemmed | Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential |
title_short | Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential |
title_sort | individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333379/ https://www.ncbi.nlm.nih.gov/pubmed/37429936 http://dx.doi.org/10.1038/s41467-023-39835-1 |
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