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The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review

Stem cells have been the subject of research for years due to their enormous therapeutic potential. Most neurological diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are in...

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Autores principales: Cecerska-Heryć, Elżbieta, Pękała, Maja, Serwin, Natalia, Gliźniewicz, Marta, Grygorcewicz, Bartłomiej, Michalczyk, Anna, Heryć, Rafał, Budkowska, Marta, Dołęgowska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333383/
https://www.ncbi.nlm.nih.gov/pubmed/37027074
http://dx.doi.org/10.1007/s10571-023-01344-6
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author Cecerska-Heryć, Elżbieta
Pękała, Maja
Serwin, Natalia
Gliźniewicz, Marta
Grygorcewicz, Bartłomiej
Michalczyk, Anna
Heryć, Rafał
Budkowska, Marta
Dołęgowska, Barbara
author_facet Cecerska-Heryć, Elżbieta
Pękała, Maja
Serwin, Natalia
Gliźniewicz, Marta
Grygorcewicz, Bartłomiej
Michalczyk, Anna
Heryć, Rafał
Budkowska, Marta
Dołęgowska, Barbara
author_sort Cecerska-Heryć, Elżbieta
collection PubMed
description Stem cells have been the subject of research for years due to their enormous therapeutic potential. Most neurological diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are incurable or very difficult to treat. Therefore new therapies are sought in which autologous stem cells are used. They are often the patient's only hope for recovery or slowing down the progress of the disease symptoms. The most important conclusions arise after analyzing the literature on the use of stem cells in neurodegenerative diseases. The effectiveness of MSC cell therapy has been confirmed in ALS and HD therapy. MSC cells slow down ALS progression and show early promising signs of efficacy. In HD, they reduced huntingtin (Htt) aggregation and stimulation of endogenous neurogenesis. MS therapy with hematopoietic stem cells (HSCs) inducted significant recalibration of pro-inflammatory and immunoregulatory components of the immune system. iPSC cells allow for accurate PD modeling. They are patient—specific and therefore minimize the risk of immune rejection and, in long-term observation, did not form any tumors in the brain. Extracellular vesicles derived from bone marrow mesenchymal stromal cells (BM-MSC-EVs) and Human adipose-derived stromal/stem cells (hASCs) cells are widely used to treat AD. Due to the reduction of Aβ42 deposits and increasing the survival of neurons, they improve memory and learning abilities. Despite many animal models and clinical trial studies, cell therapy still needs to be refined to increase its effectiveness in the human body. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-103333832023-07-12 The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review Cecerska-Heryć, Elżbieta Pękała, Maja Serwin, Natalia Gliźniewicz, Marta Grygorcewicz, Bartłomiej Michalczyk, Anna Heryć, Rafał Budkowska, Marta Dołęgowska, Barbara Cell Mol Neurobiol Review Paper Stem cells have been the subject of research for years due to their enormous therapeutic potential. Most neurological diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are incurable or very difficult to treat. Therefore new therapies are sought in which autologous stem cells are used. They are often the patient's only hope for recovery or slowing down the progress of the disease symptoms. The most important conclusions arise after analyzing the literature on the use of stem cells in neurodegenerative diseases. The effectiveness of MSC cell therapy has been confirmed in ALS and HD therapy. MSC cells slow down ALS progression and show early promising signs of efficacy. In HD, they reduced huntingtin (Htt) aggregation and stimulation of endogenous neurogenesis. MS therapy with hematopoietic stem cells (HSCs) inducted significant recalibration of pro-inflammatory and immunoregulatory components of the immune system. iPSC cells allow for accurate PD modeling. They are patient—specific and therefore minimize the risk of immune rejection and, in long-term observation, did not form any tumors in the brain. Extracellular vesicles derived from bone marrow mesenchymal stromal cells (BM-MSC-EVs) and Human adipose-derived stromal/stem cells (hASCs) cells are widely used to treat AD. Due to the reduction of Aβ42 deposits and increasing the survival of neurons, they improve memory and learning abilities. Despite many animal models and clinical trial studies, cell therapy still needs to be refined to increase its effectiveness in the human body. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2023-04-07 2023 /pmc/articles/PMC10333383/ /pubmed/37027074 http://dx.doi.org/10.1007/s10571-023-01344-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Paper
Cecerska-Heryć, Elżbieta
Pękała, Maja
Serwin, Natalia
Gliźniewicz, Marta
Grygorcewicz, Bartłomiej
Michalczyk, Anna
Heryć, Rafał
Budkowska, Marta
Dołęgowska, Barbara
The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review
title The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review
title_full The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review
title_fullStr The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review
title_full_unstemmed The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review
title_short The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review
title_sort use of stem cells as a potential treatment method for selected neurodegenerative diseases: review
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333383/
https://www.ncbi.nlm.nih.gov/pubmed/37027074
http://dx.doi.org/10.1007/s10571-023-01344-6
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