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Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma

INTRODUCTION: CD155 is recently emerging as a promising target in malignancies. However, the relationship between CD155 expression and tumor microenvironment (TME) cell infiltration in gastric adenocarcinoma (GAC) has rarely been clarified. METHODS: We measured CD155 expression in specimens of gastr...

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Autores principales: Liu, Xue, Xu, Chenyang, Guo, Tianwei, Zhan, Shenghua, Quan, Qiuying, Li, Mengsi, Wang, Ziyi, Zhang, Xueguang, Guo, Lingchuan, Cao, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333512/
https://www.ncbi.nlm.nih.gov/pubmed/37441080
http://dx.doi.org/10.3389/fimmu.2023.1173524
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author Liu, Xue
Xu, Chenyang
Guo, Tianwei
Zhan, Shenghua
Quan, Qiuying
Li, Mengsi
Wang, Ziyi
Zhang, Xueguang
Guo, Lingchuan
Cao, Lei
author_facet Liu, Xue
Xu, Chenyang
Guo, Tianwei
Zhan, Shenghua
Quan, Qiuying
Li, Mengsi
Wang, Ziyi
Zhang, Xueguang
Guo, Lingchuan
Cao, Lei
author_sort Liu, Xue
collection PubMed
description INTRODUCTION: CD155 is recently emerging as a promising target in malignancies. However, the relationship between CD155 expression and tumor microenvironment (TME) cell infiltration in gastric adenocarcinoma (GAC) has rarely been clarified. METHODS: We measured CD155 expression in specimens of gastric precancerous disease and GAC by immunohistochemistry. The association of CD155 expression with GAC progression and cells infiltration in TME was evaluated through 268 GAC tissues and public dataset analysis. RESULTS: We showed that the expression of CD155 was positively correlated with the pathological development of gastric precancerous disease (r = 0.521, P < 0.0001). GAC patients with high CD155 expression had a poorer overall survival (P = 0.033). Moreover, CD155 expression correlated with aggressive clinicopathological features including tumor volume, tumor stage, lymph node involvement, and cell proliferation (P <0.05). Remarkably, CD155 expression positively related to the infiltration of CD68+ macrophages in TME (P = 0.011). Meanwhile, the positive correlation was observed between CD155 and CD31 (P = 0.026). In addition, patients with high CD155 expression combined with low CD3, CD4, CD8, IL-17, IFN-γ or CD19 expression as well as those with high CD155 and α-SMA expression showed significantly worse overall survival (P < 0.05). CONCLUSIONS: CD155 may play a pivotal role in the development of GAC through both immunological and non-immunological mechanisms and be expected to become a novel target of immunotherapy in GAC patients.
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spelling pubmed-103335122023-07-12 Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma Liu, Xue Xu, Chenyang Guo, Tianwei Zhan, Shenghua Quan, Qiuying Li, Mengsi Wang, Ziyi Zhang, Xueguang Guo, Lingchuan Cao, Lei Front Immunol Immunology INTRODUCTION: CD155 is recently emerging as a promising target in malignancies. However, the relationship between CD155 expression and tumor microenvironment (TME) cell infiltration in gastric adenocarcinoma (GAC) has rarely been clarified. METHODS: We measured CD155 expression in specimens of gastric precancerous disease and GAC by immunohistochemistry. The association of CD155 expression with GAC progression and cells infiltration in TME was evaluated through 268 GAC tissues and public dataset analysis. RESULTS: We showed that the expression of CD155 was positively correlated with the pathological development of gastric precancerous disease (r = 0.521, P < 0.0001). GAC patients with high CD155 expression had a poorer overall survival (P = 0.033). Moreover, CD155 expression correlated with aggressive clinicopathological features including tumor volume, tumor stage, lymph node involvement, and cell proliferation (P <0.05). Remarkably, CD155 expression positively related to the infiltration of CD68+ macrophages in TME (P = 0.011). Meanwhile, the positive correlation was observed between CD155 and CD31 (P = 0.026). In addition, patients with high CD155 expression combined with low CD3, CD4, CD8, IL-17, IFN-γ or CD19 expression as well as those with high CD155 and α-SMA expression showed significantly worse overall survival (P < 0.05). CONCLUSIONS: CD155 may play a pivotal role in the development of GAC through both immunological and non-immunological mechanisms and be expected to become a novel target of immunotherapy in GAC patients. Frontiers Media S.A. 2023-06-27 /pmc/articles/PMC10333512/ /pubmed/37441080 http://dx.doi.org/10.3389/fimmu.2023.1173524 Text en Copyright © 2023 Liu, Xu, Guo, Zhan, Quan, Li, Wang, Zhang, Guo and Cao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Xue
Xu, Chenyang
Guo, Tianwei
Zhan, Shenghua
Quan, Qiuying
Li, Mengsi
Wang, Ziyi
Zhang, Xueguang
Guo, Lingchuan
Cao, Lei
Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma
title Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma
title_full Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma
title_fullStr Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma
title_full_unstemmed Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma
title_short Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma
title_sort clinical significance of cd155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333512/
https://www.ncbi.nlm.nih.gov/pubmed/37441080
http://dx.doi.org/10.3389/fimmu.2023.1173524
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