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Structural transitions in TCTP tumor protein upon binding to the anti-apoptotic protein family member Mcl-1

Translationally Controlled Tumor Protein (TCTP) serves as a pro-survival factor in tumor cells, inhibiting the mitochondrial apoptosis pathway by enhancing the function of anti-apoptotic Bcl-2 family members Mcl-1 and Bcl-xL. TCTP specifically binds to Bcl-xL, preventing Bax-dependent Bcl-xL-induced...

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Detalles Bibliográficos
Autores principales:	Malard, Florian, Sizun, Christina, Thureau, Aurélien, Carlier, Ludovic, Lescop, Ewen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333598/ https://www.ncbi.nlm.nih.gov/pubmed/37201583 http://dx.doi.org/10.1016/j.jbc.2023.104830

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