Ameliorative effect of ethanolic extract of Carica papaya leaves on hyper-cholesterolemic rats: The egg yolk induced model

Cardiovascular disease is one of the leading killers in the world today, and hyperlipidemia is one of the main risk factors. The prevalence of hyperlipidemia is rising dramatically worldwide and is mostly felt in poorer nations. The majority of communities and individuals in Africa are known to turn to ethnomedicine for their medical requirements. The tropical plant Carica papaya, which is grown for its edible, ripe fruit in Africa, was used in folk medicine for treatment of cardiovascular issues as well as a number of serious illnesses. This study assessed the anticholesterolemic property of the ethanolic extracts of Carica papaya leaves, adapting the egg yolk-induced hyperlipidaemia model in Wistar albino rats. This study prepared egg yolk to induce hyperlipidaemia in the Wistar rats, then treated some groups with the extract of Carica papaya leaves, and other groups with the standard drug Fenofibrate. The Wistar rats in the control group were given 2% acacia instead of egg yolk. The total cholesterol, triglycerides, as well as biological and haematological parameters, were determined. The Carica papaya leaves extracts significantly (p<0.05) decreased the total cholesterol and LDL cholesterol levels at all doses administered, but the extract and the standard drug had no significant effect on HDL cholesterol. An inverse relationship between the Carica papaya leaves extract doses and the cholesterol levels was observed placing the efficacy in the order of 100 mg/kg > 250 mg/kg > Fenofibrate (2.29 mg/kg) > 500 mg/kg. With the potential efficacy of Carica papaya leaves extract in the treatment of hypercholesterolemia and, as a result, cardiovascular diseases, more research on bioactive molecule isolation/characterisation for pharmaceutical use or incorporation into functional food products for CVD management is required.