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Recent advances in CD8(+) T cell-based immune therapies for HIV cure

Achieving a cure for HIV infection is a global priority. There is substantial evidence supporting a central role for CD8(+) T cells in the natural control of HIV, suggesting the rationale that these cells may be exploited to achieve remission or cure of this infection. In this work, we review the ma...

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Autores principales: Arenas, Valentina Restrepo, Rugeles, María T., Perdomo-Celis, Federico, Taborda, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333625/
https://www.ncbi.nlm.nih.gov/pubmed/37441388
http://dx.doi.org/10.1016/j.heliyon.2023.e17481
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author Arenas, Valentina Restrepo
Rugeles, María T.
Perdomo-Celis, Federico
Taborda, Natalia
author_facet Arenas, Valentina Restrepo
Rugeles, María T.
Perdomo-Celis, Federico
Taborda, Natalia
author_sort Arenas, Valentina Restrepo
collection PubMed
description Achieving a cure for HIV infection is a global priority. There is substantial evidence supporting a central role for CD8(+) T cells in the natural control of HIV, suggesting the rationale that these cells may be exploited to achieve remission or cure of this infection. In this work, we review the major challenges for achieving an HIV cure, the models of HIV remission, and the mechanisms of HIV control mediated by CD8(+) T cells. In addition, we discuss strategies based on this cell population that could be used in the search for an HIV cure. Finally, we analyze the current challenges and perspectives to translate this basic knowledge toward scalable HIV cure strategies.
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spelling pubmed-103336252023-07-12 Recent advances in CD8(+) T cell-based immune therapies for HIV cure Arenas, Valentina Restrepo Rugeles, María T. Perdomo-Celis, Federico Taborda, Natalia Heliyon Review Article Achieving a cure for HIV infection is a global priority. There is substantial evidence supporting a central role for CD8(+) T cells in the natural control of HIV, suggesting the rationale that these cells may be exploited to achieve remission or cure of this infection. In this work, we review the major challenges for achieving an HIV cure, the models of HIV remission, and the mechanisms of HIV control mediated by CD8(+) T cells. In addition, we discuss strategies based on this cell population that could be used in the search for an HIV cure. Finally, we analyze the current challenges and perspectives to translate this basic knowledge toward scalable HIV cure strategies. Elsevier 2023-06-20 /pmc/articles/PMC10333625/ /pubmed/37441388 http://dx.doi.org/10.1016/j.heliyon.2023.e17481 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Arenas, Valentina Restrepo
Rugeles, María T.
Perdomo-Celis, Federico
Taborda, Natalia
Recent advances in CD8(+) T cell-based immune therapies for HIV cure
title Recent advances in CD8(+) T cell-based immune therapies for HIV cure
title_full Recent advances in CD8(+) T cell-based immune therapies for HIV cure
title_fullStr Recent advances in CD8(+) T cell-based immune therapies for HIV cure
title_full_unstemmed Recent advances in CD8(+) T cell-based immune therapies for HIV cure
title_short Recent advances in CD8(+) T cell-based immune therapies for HIV cure
title_sort recent advances in cd8(+) t cell-based immune therapies for hiv cure
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333625/
https://www.ncbi.nlm.nih.gov/pubmed/37441388
http://dx.doi.org/10.1016/j.heliyon.2023.e17481
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