Pancreatic beta-cell specific BAG3 knockout results in chronic hyperinsulinemia inducing insulin resistance

BACKGROUND: Insulin, secreted from pancreatic islets of Langerhans, is of critical importance in regulating glucose homeostasis. Defective insulin secretion and/or the inability of tissues to respond to insulin results in insulin resistance and to several metabolic and organ alterations. We have pre...

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Detalles Bibliográficos
Autores principales: Damiani, Verena, Lamolinara, Alessia, Cicalini, Ilaria, Cufaro, Maria Concetta, Del Pizzo, Francesco, Di Marco, Federica, Del Boccio, Piero, Dufrusine, Beatrice, Hahne, Michael, Lattanzio, Rossano, Pieragostino, Damiana, Iezzi, Manuela, Federici, Massimo, Turco, Maria Caterina, Maiorana, Arianna, Dionisi-Vici, Carlo, De Laurenzi, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333681/
https://www.ncbi.nlm.nih.gov/pubmed/37308077
http://dx.doi.org/10.1016/j.molmet.2023.101752

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