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Versatile delivery platform for nucleic acids, negatively charged protein drugs, and genome-editing ribonucleoproteins using a multi-step transformable polyrotaxane

Various biopharmaceuticals, such as nucleic acids, proteins, and genome-editing molecules, have been developed. Generally, carriers are prepared for each biopharmaceutical to deliver it intracellularly; thus, the applications of individual carriers are limited. Moreover, the development of carriers...

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Detalles Bibliográficos
Autores principales: Taharabaru, Toru, Kihara, Takuya, Onodera, Risako, Kogo, Tetsuya, Wen, Yuting, Li, Jun, Motoyama, Keiichi, Higashi, Taishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333717/
https://www.ncbi.nlm.nih.gov/pubmed/37441133
http://dx.doi.org/10.1016/j.mtbio.2023.100690