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Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements
INTRODUCTION: Trace elements play a key role in dental tissue development, as dental hard tissues accumulate both essential and toxic trace elements during mineralization. Characterization of the spatial accumulation pattern of trace elements may provide insight into exposure to toxic elements over...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333753/ https://www.ncbi.nlm.nih.gov/pubmed/37441556 http://dx.doi.org/10.3389/fvets.2023.1204210 |
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author | Wright, Alexandra L. Fiani, Nadine Peralta, Santiago Arora, Manish Austin, Christine |
author_facet | Wright, Alexandra L. Fiani, Nadine Peralta, Santiago Arora, Manish Austin, Christine |
author_sort | Wright, Alexandra L. |
collection | PubMed |
description | INTRODUCTION: Trace elements play a key role in dental tissue development, as dental hard tissues accumulate both essential and toxic trace elements during mineralization. Characterization of the spatial accumulation pattern of trace elements may provide insight into exposure to toxic elements over time and to the nature of disease processes affecting the hard dental tissues. Here, we present the first report of the use of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) to map the microspatial distribution of multiple trace elements, essential and toxic, across feline dental hard tissues. METHODS: Eleven teeth were extracted from 8 cats. Nine teeth were from 7 cats diagnosed with idiopathic tooth resorption on intraoral radiographs prior to extraction. Two teeth were included from a cadaver that had no signs of tooth resorption on intraoral radiographs. The normal dental tissue was analyzed from each sample using LA-ICP-MS to map the microspatial distribution of essential and toxic trace elements across feline enamel, dentin, and cementum. RESULTS: Results showed a higher accumulation of barium and strontium in coronal dentin as compared to root dentin. The timing of the accumulation mirrors nursing timelines seen in teeth from human and non-human primates, consistent with barium and strontium being sourced from maternal milk. Results also showed a higher uptake of lead in the coronal dentin, suggesting this lead exposure was likely passed from mother to offspring. DISCUSSION: This work characterizes a baseline for elemental distribution in feline teeth linked to early life exposure to toxic elements such as lead and provides a framework for future studies investigating long-term environmental exposures to trace elements, essential and toxic, and their involvement in feline systemic and dental diseases. |
format | Online Article Text |
id | pubmed-10333753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103337532023-07-12 Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements Wright, Alexandra L. Fiani, Nadine Peralta, Santiago Arora, Manish Austin, Christine Front Vet Sci Veterinary Science INTRODUCTION: Trace elements play a key role in dental tissue development, as dental hard tissues accumulate both essential and toxic trace elements during mineralization. Characterization of the spatial accumulation pattern of trace elements may provide insight into exposure to toxic elements over time and to the nature of disease processes affecting the hard dental tissues. Here, we present the first report of the use of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) to map the microspatial distribution of multiple trace elements, essential and toxic, across feline dental hard tissues. METHODS: Eleven teeth were extracted from 8 cats. Nine teeth were from 7 cats diagnosed with idiopathic tooth resorption on intraoral radiographs prior to extraction. Two teeth were included from a cadaver that had no signs of tooth resorption on intraoral radiographs. The normal dental tissue was analyzed from each sample using LA-ICP-MS to map the microspatial distribution of essential and toxic trace elements across feline enamel, dentin, and cementum. RESULTS: Results showed a higher accumulation of barium and strontium in coronal dentin as compared to root dentin. The timing of the accumulation mirrors nursing timelines seen in teeth from human and non-human primates, consistent with barium and strontium being sourced from maternal milk. Results also showed a higher uptake of lead in the coronal dentin, suggesting this lead exposure was likely passed from mother to offspring. DISCUSSION: This work characterizes a baseline for elemental distribution in feline teeth linked to early life exposure to toxic elements such as lead and provides a framework for future studies investigating long-term environmental exposures to trace elements, essential and toxic, and their involvement in feline systemic and dental diseases. Frontiers Media S.A. 2023-06-27 /pmc/articles/PMC10333753/ /pubmed/37441556 http://dx.doi.org/10.3389/fvets.2023.1204210 Text en Copyright © 2023 Wright, Fiani, Peralta, Arora and Austin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Wright, Alexandra L. Fiani, Nadine Peralta, Santiago Arora, Manish Austin, Christine Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements |
title | Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements |
title_full | Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements |
title_fullStr | Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements |
title_full_unstemmed | Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements |
title_short | Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements |
title_sort | microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333753/ https://www.ncbi.nlm.nih.gov/pubmed/37441556 http://dx.doi.org/10.3389/fvets.2023.1204210 |
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