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Inoculum-dependent bactericidal activity of a Mycobacterium tuberculosis MmpL3 inhibitor

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Indolcarboxamides are a promising series of anti-tubercular agents, which target Mycobacterium tuberculosis MmpL3, the exporter of trehalose monomycolate, a key cell-wall component. We determined the kill kinetics of the lead indolcarboxamide NITD-349 and determined that while kill was rapid against...

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Detalles Bibliográficos
Autores principales:	Berube, Bryan, Deshpande, Aditi, Bhagwat, Amala, Parish, Tanya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Microbiology Society 2023
Materias:	Antimicrobials and AMR
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333795/ https://www.ncbi.nlm.nih.gov/pubmed/37334886 http://dx.doi.org/10.1099/mic.0.001345

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