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Evolution of cyclic di-GMP signalling on a short and long term time scale

Diversifying radiation of domain families within specific lineages of life indicates the importance of their functionality for the organisms. The foundation for the diversifying radiation of the cyclic di-GMP signalling network that occurred within the bacterial kingdom is most likely based in the o...

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Autores principales: Römling, Ute, Cao, Lian-Ying, Bai, Feng-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333796/
https://www.ncbi.nlm.nih.gov/pubmed/37384391
http://dx.doi.org/10.1099/mic.0.001354
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author Römling, Ute
Cao, Lian-Ying
Bai, Feng-Wu
author_facet Römling, Ute
Cao, Lian-Ying
Bai, Feng-Wu
author_sort Römling, Ute
collection PubMed
description Diversifying radiation of domain families within specific lineages of life indicates the importance of their functionality for the organisms. The foundation for the diversifying radiation of the cyclic di-GMP signalling network that occurred within the bacterial kingdom is most likely based in the outmost adaptability, flexibility and plasticity of the system. Integrative sensing of multiple diverse extra- and intracellular signals is made possible by the N-terminal sensory domains of the modular cyclic di-GMP turnover proteins, mutations in the protein scaffolds and subsequent signal reception by diverse receptors, which eventually rewires opposite host-associated as well as environmental life styles including parallel regulated target outputs. Natural, laboratory and microcosm derived microbial variants often with an altered multicellular biofilm behaviour as reading output demonstrated single amino acid substitutions to substantially alter catalytic activity including substrate specificity. Truncations and domain swapping of cyclic di-GMP signalling genes and horizontal gene transfer suggest rewiring of the network. Presence of cyclic di-GMP signalling genes on horizontally transferable elements in particular observed in extreme acidophilic bacteria indicates that cyclic di-GMP signalling and biofilm components are under selective pressure in these types of environments. On a short and long term evolutionary scale, within a species and in families within bacterial orders, respectively, the cyclic di-GMP signalling network can also rapidly disappear. To investigate variability of the cyclic di-GMP signalling system on various levels will give clues about evolutionary forces and discover novel physiological and metabolic pathways affected by this intriguing second messenger signalling system.
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spelling pubmed-103337962023-07-12 Evolution of cyclic di-GMP signalling on a short and long term time scale Römling, Ute Cao, Lian-Ying Bai, Feng-Wu Microbiology (Reading) Microbial Evolution Diversifying radiation of domain families within specific lineages of life indicates the importance of their functionality for the organisms. The foundation for the diversifying radiation of the cyclic di-GMP signalling network that occurred within the bacterial kingdom is most likely based in the outmost adaptability, flexibility and plasticity of the system. Integrative sensing of multiple diverse extra- and intracellular signals is made possible by the N-terminal sensory domains of the modular cyclic di-GMP turnover proteins, mutations in the protein scaffolds and subsequent signal reception by diverse receptors, which eventually rewires opposite host-associated as well as environmental life styles including parallel regulated target outputs. Natural, laboratory and microcosm derived microbial variants often with an altered multicellular biofilm behaviour as reading output demonstrated single amino acid substitutions to substantially alter catalytic activity including substrate specificity. Truncations and domain swapping of cyclic di-GMP signalling genes and horizontal gene transfer suggest rewiring of the network. Presence of cyclic di-GMP signalling genes on horizontally transferable elements in particular observed in extreme acidophilic bacteria indicates that cyclic di-GMP signalling and biofilm components are under selective pressure in these types of environments. On a short and long term evolutionary scale, within a species and in families within bacterial orders, respectively, the cyclic di-GMP signalling network can also rapidly disappear. To investigate variability of the cyclic di-GMP signalling system on various levels will give clues about evolutionary forces and discover novel physiological and metabolic pathways affected by this intriguing second messenger signalling system. Microbiology Society 2023-06-29 /pmc/articles/PMC10333796/ /pubmed/37384391 http://dx.doi.org/10.1099/mic.0.001354 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
spellingShingle Microbial Evolution
Römling, Ute
Cao, Lian-Ying
Bai, Feng-Wu
Evolution of cyclic di-GMP signalling on a short and long term time scale
title Evolution of cyclic di-GMP signalling on a short and long term time scale
title_full Evolution of cyclic di-GMP signalling on a short and long term time scale
title_fullStr Evolution of cyclic di-GMP signalling on a short and long term time scale
title_full_unstemmed Evolution of cyclic di-GMP signalling on a short and long term time scale
title_short Evolution of cyclic di-GMP signalling on a short and long term time scale
title_sort evolution of cyclic di-gmp signalling on a short and long term time scale
topic Microbial Evolution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333796/
https://www.ncbi.nlm.nih.gov/pubmed/37384391
http://dx.doi.org/10.1099/mic.0.001354
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