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Interaction between SIRT1 and non-coding RNAs in different disorders
SIRT1 is a member of the sirtuin family functioning in the process of removal of acetyl groups from different proteins. This protein has several biological functions and is involved in the pathogenesis of metabolic diseases, malignancy, aging, neurodegenerative disorders and inflammation. Several lo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333929/ https://www.ncbi.nlm.nih.gov/pubmed/37441551 http://dx.doi.org/10.3389/fgene.2023.1121982 |
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author | Ghafouri-Fard, Soudeh Shoorei, Hamed Hussen, Bashdar Mahmud Poornajaf, Yadollah Taheri, Mohammad Sharifi, Guive |
author_facet | Ghafouri-Fard, Soudeh Shoorei, Hamed Hussen, Bashdar Mahmud Poornajaf, Yadollah Taheri, Mohammad Sharifi, Guive |
author_sort | Ghafouri-Fard, Soudeh |
collection | PubMed |
description | SIRT1 is a member of the sirtuin family functioning in the process of removal of acetyl groups from different proteins. This protein has several biological functions and is involved in the pathogenesis of metabolic diseases, malignancy, aging, neurodegenerative disorders and inflammation. Several long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs) have been found to interact with SIRT1. These interactions have been assessed in the contexts of sepsis, cardiomyopathy, heart failure, non-alcoholic fatty liver disease, chronic hepatitis, cardiac fibrosis, myocardial ischemia/reperfusion injury, diabetes, ischemic stroke, immune-related disorders and cancers. Notably, SIRT1-interacting non-coding RNAs have been found to interact with each other. Several circRNA/miRNA and lncRNA/miRNA pairs that interact with SIRT1 have been identified. These axes are potential targets for design of novel therapies for different disorders. In the current review, we summarize the interactions between three classes of non-coding RNAs and SIRT1. |
format | Online Article Text |
id | pubmed-10333929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103339292023-07-12 Interaction between SIRT1 and non-coding RNAs in different disorders Ghafouri-Fard, Soudeh Shoorei, Hamed Hussen, Bashdar Mahmud Poornajaf, Yadollah Taheri, Mohammad Sharifi, Guive Front Genet Genetics SIRT1 is a member of the sirtuin family functioning in the process of removal of acetyl groups from different proteins. This protein has several biological functions and is involved in the pathogenesis of metabolic diseases, malignancy, aging, neurodegenerative disorders and inflammation. Several long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs) have been found to interact with SIRT1. These interactions have been assessed in the contexts of sepsis, cardiomyopathy, heart failure, non-alcoholic fatty liver disease, chronic hepatitis, cardiac fibrosis, myocardial ischemia/reperfusion injury, diabetes, ischemic stroke, immune-related disorders and cancers. Notably, SIRT1-interacting non-coding RNAs have been found to interact with each other. Several circRNA/miRNA and lncRNA/miRNA pairs that interact with SIRT1 have been identified. These axes are potential targets for design of novel therapies for different disorders. In the current review, we summarize the interactions between three classes of non-coding RNAs and SIRT1. Frontiers Media S.A. 2023-06-27 /pmc/articles/PMC10333929/ /pubmed/37441551 http://dx.doi.org/10.3389/fgene.2023.1121982 Text en Copyright © 2023 Ghafouri-Fard, Shoorei, Hussen, Poornajaf, Taheri and Sharifi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Ghafouri-Fard, Soudeh Shoorei, Hamed Hussen, Bashdar Mahmud Poornajaf, Yadollah Taheri, Mohammad Sharifi, Guive Interaction between SIRT1 and non-coding RNAs in different disorders |
title | Interaction between SIRT1 and non-coding RNAs in different disorders |
title_full | Interaction between SIRT1 and non-coding RNAs in different disorders |
title_fullStr | Interaction between SIRT1 and non-coding RNAs in different disorders |
title_full_unstemmed | Interaction between SIRT1 and non-coding RNAs in different disorders |
title_short | Interaction between SIRT1 and non-coding RNAs in different disorders |
title_sort | interaction between sirt1 and non-coding rnas in different disorders |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333929/ https://www.ncbi.nlm.nih.gov/pubmed/37441551 http://dx.doi.org/10.3389/fgene.2023.1121982 |
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