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Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans

The gut microbiome has a profound influence on host physiology, including energy metabolism, which is the process by which energy from nutrients is transformed into other forms of energy to be used by the body. However, mechanistic evidence for how the microbiome influences energy metabolism is deri...

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Autores principales: Montenegro, Julia, Armet, Anissa M., Willing, Benjamin P., Deehan, Edward C., Fassini, Priscila G., Mota, João F., Walter, Jens, Prado, Carla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Nutrition 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334151/
https://www.ncbi.nlm.nih.gov/pubmed/37031749
http://dx.doi.org/10.1016/j.advnut.2023.03.015
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author Montenegro, Julia
Armet, Anissa M.
Willing, Benjamin P.
Deehan, Edward C.
Fassini, Priscila G.
Mota, João F.
Walter, Jens
Prado, Carla M.
author_facet Montenegro, Julia
Armet, Anissa M.
Willing, Benjamin P.
Deehan, Edward C.
Fassini, Priscila G.
Mota, João F.
Walter, Jens
Prado, Carla M.
author_sort Montenegro, Julia
collection PubMed
description The gut microbiome has a profound influence on host physiology, including energy metabolism, which is the process by which energy from nutrients is transformed into other forms of energy to be used by the body. However, mechanistic evidence for how the microbiome influences energy metabolism is derived from animal models. In this narrative review, we included human studies investigating the relationship between gut microbiome and energy metabolism —i.e., energy expenditure in humans and energy harvest by the gut microbiome. Studies have found no consistent gut microbiome patterns associated with energy metabolism, and most interventions were not effective in modulating the gut microbiome to influence energy metabolism. To date, cause-and-effect relationships and mechanistic evidence on the impact of the gut microbiome on energy expenditure have not been established in humans. Future longitudinal observational studies and randomized controlled trials utilizing robust methodologies and advanced statistical analysis are needed. Such knowledge would potentially inform the design of therapeutic avenues and specific dietary recommendations to improve energy metabolism through gut microbiome modulation.
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spelling pubmed-103341512023-07-12 Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans Montenegro, Julia Armet, Anissa M. Willing, Benjamin P. Deehan, Edward C. Fassini, Priscila G. Mota, João F. Walter, Jens Prado, Carla M. Adv Nutr Review The gut microbiome has a profound influence on host physiology, including energy metabolism, which is the process by which energy from nutrients is transformed into other forms of energy to be used by the body. However, mechanistic evidence for how the microbiome influences energy metabolism is derived from animal models. In this narrative review, we included human studies investigating the relationship between gut microbiome and energy metabolism —i.e., energy expenditure in humans and energy harvest by the gut microbiome. Studies have found no consistent gut microbiome patterns associated with energy metabolism, and most interventions were not effective in modulating the gut microbiome to influence energy metabolism. To date, cause-and-effect relationships and mechanistic evidence on the impact of the gut microbiome on energy expenditure have not been established in humans. Future longitudinal observational studies and randomized controlled trials utilizing robust methodologies and advanced statistical analysis are needed. Such knowledge would potentially inform the design of therapeutic avenues and specific dietary recommendations to improve energy metabolism through gut microbiome modulation. American Society for Nutrition 2023-04-07 /pmc/articles/PMC10334151/ /pubmed/37031749 http://dx.doi.org/10.1016/j.advnut.2023.03.015 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Montenegro, Julia
Armet, Anissa M.
Willing, Benjamin P.
Deehan, Edward C.
Fassini, Priscila G.
Mota, João F.
Walter, Jens
Prado, Carla M.
Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans
title Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans
title_full Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans
title_fullStr Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans
title_full_unstemmed Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans
title_short Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans
title_sort exploring the influence of gut microbiome on energy metabolism in humans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334151/
https://www.ncbi.nlm.nih.gov/pubmed/37031749
http://dx.doi.org/10.1016/j.advnut.2023.03.015
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