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Hybrid neural network approaches to predict drug–target binding affinity for drug repurposing: screening for potential leads for Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disease that primarily affects elderly individuals. Recent studies have found that sigma-1 receptor (S1R) agonists can maintain endoplasmic reticulum stress homeostasis, reduce neuronal apoptosis, and enhance mitochondrial function and autophagy, makin...

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Detalles Bibliográficos
Autores principales:	Wu, Xialin, Li, Zhuojian, Chen, Guanxing, Yin, Yiyang, Chen, Calvin Yu-Chian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334190/ https://www.ncbi.nlm.nih.gov/pubmed/37441162 http://dx.doi.org/10.3389/fmolb.2023.1227371

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