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Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial

IMPORTANCE: Egg introduction in infants at age 4 to 6 months is associated with a lower risk of immunoglobulin E–mediated egg allergy (EA). However, whether their risk of EA at age 12 months is affected by maternal intake of eggs at birth is unknown. OBJECTIVE: To determine the effect of maternal eg...

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Autores principales: Nagakura, Ken-ichi, Sato, Sakura, Shinahara, Wakako, Kido, Hiroshi, Fujita, Hidetoshi, Yanai, Takanori, Akiyama, Nao, Futamura, Masaki, Koga, Hiroshi, Fujiwara, Michimasa, Kaneko, Hideo, Taniguchi, Hiroaki, Makita, Eishi, Takahashi, Kyohei, Yanagida, Noriyuki, Ebisawa, Motohiro, Urashima, Mitsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334231/
https://www.ncbi.nlm.nih.gov/pubmed/37428506
http://dx.doi.org/10.1001/jamanetworkopen.2023.22318
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author Nagakura, Ken-ichi
Sato, Sakura
Shinahara, Wakako
Kido, Hiroshi
Fujita, Hidetoshi
Yanai, Takanori
Akiyama, Nao
Futamura, Masaki
Koga, Hiroshi
Fujiwara, Michimasa
Kaneko, Hideo
Taniguchi, Hiroaki
Makita, Eishi
Takahashi, Kyohei
Yanagida, Noriyuki
Ebisawa, Motohiro
Urashima, Mitsuyoshi
author_facet Nagakura, Ken-ichi
Sato, Sakura
Shinahara, Wakako
Kido, Hiroshi
Fujita, Hidetoshi
Yanai, Takanori
Akiyama, Nao
Futamura, Masaki
Koga, Hiroshi
Fujiwara, Michimasa
Kaneko, Hideo
Taniguchi, Hiroaki
Makita, Eishi
Takahashi, Kyohei
Yanagida, Noriyuki
Ebisawa, Motohiro
Urashima, Mitsuyoshi
author_sort Nagakura, Ken-ichi
collection PubMed
description IMPORTANCE: Egg introduction in infants at age 4 to 6 months is associated with a lower risk of immunoglobulin E–mediated egg allergy (EA). However, whether their risk of EA at age 12 months is affected by maternal intake of eggs at birth is unknown. OBJECTIVE: To determine the effect of maternal egg intake during the early neonatal period (0-5 days) on the development of EA in breastfed infants at age 12 months. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, single-blind (outcome data evaluators), randomized clinical trial was conducted from December 18, 2017, to May 31, 2021, at 10 medical facilities in Japan. Newborns with at least 1 of 2 parents having an allergic disease were included. Neonates whose mothers had EA or were unable to consume breast milk after the age of 2 days were excluded. Data were analyzed on an intention-to-treat basis. INTERVENTIONS: Newborns were randomized (1:1) to a maternal egg consumption (MEC) group, wherein the mothers consumed 1 whole egg per day during the first 5 days of the neonate’s life, and a maternal egg elimination (MEE) group, wherein the mothers eliminated eggs from their diet during the same period. MAIN OUTCOMES AND MEASURES: The primary outcome was EA at age 12 months. Egg allergy was defined as sensitization to egg white or ovomucoid plus a positive test result in an oral food challenge or an episode of obvious immediate symptoms after egg ingestion. RESULTS: Of the 380 newborns included (198 [52.1%] female), 367 (MEC: n = 183; MEE: n = 184) were followed up for 12 months. On days 3 and 4 after delivery, the proportions of neonates with ovalbumin and ovomucoid detection in breast milk were higher in the MEC group than in the MEE group (ovalbumin: 10.7% vs 2.0%; risk ratio [RR], 5.23; 95% CI, 1.56-17.56; ovomucoid: 11.3% vs 2.0%; RR, 5.55; 95% CI, 1.66-18.55). At age 12 months, the MEC and MEE groups did not differ significantly in EA (9.3% vs 7.6%; RR, 1.22; 95% CI, 0.62-2.40) or sensitization to egg white (62.8% vs 58.7%; RR, 1.07; 95% CI, 0.91-1.26). No adverse effects were reported. CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, EA development and sensitization to eggs were unaffected by MEC during the early neonatal period. TRIAL REGISTRATION: UMIN Clinical Trials Registry: UMIN000027593
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spelling pubmed-103342312023-07-12 Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial Nagakura, Ken-ichi Sato, Sakura Shinahara, Wakako Kido, Hiroshi Fujita, Hidetoshi Yanai, Takanori Akiyama, Nao Futamura, Masaki Koga, Hiroshi Fujiwara, Michimasa Kaneko, Hideo Taniguchi, Hiroaki Makita, Eishi Takahashi, Kyohei Yanagida, Noriyuki Ebisawa, Motohiro Urashima, Mitsuyoshi JAMA Netw Open Original Investigation IMPORTANCE: Egg introduction in infants at age 4 to 6 months is associated with a lower risk of immunoglobulin E–mediated egg allergy (EA). However, whether their risk of EA at age 12 months is affected by maternal intake of eggs at birth is unknown. OBJECTIVE: To determine the effect of maternal egg intake during the early neonatal period (0-5 days) on the development of EA in breastfed infants at age 12 months. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, single-blind (outcome data evaluators), randomized clinical trial was conducted from December 18, 2017, to May 31, 2021, at 10 medical facilities in Japan. Newborns with at least 1 of 2 parents having an allergic disease were included. Neonates whose mothers had EA or were unable to consume breast milk after the age of 2 days were excluded. Data were analyzed on an intention-to-treat basis. INTERVENTIONS: Newborns were randomized (1:1) to a maternal egg consumption (MEC) group, wherein the mothers consumed 1 whole egg per day during the first 5 days of the neonate’s life, and a maternal egg elimination (MEE) group, wherein the mothers eliminated eggs from their diet during the same period. MAIN OUTCOMES AND MEASURES: The primary outcome was EA at age 12 months. Egg allergy was defined as sensitization to egg white or ovomucoid plus a positive test result in an oral food challenge or an episode of obvious immediate symptoms after egg ingestion. RESULTS: Of the 380 newborns included (198 [52.1%] female), 367 (MEC: n = 183; MEE: n = 184) were followed up for 12 months. On days 3 and 4 after delivery, the proportions of neonates with ovalbumin and ovomucoid detection in breast milk were higher in the MEC group than in the MEE group (ovalbumin: 10.7% vs 2.0%; risk ratio [RR], 5.23; 95% CI, 1.56-17.56; ovomucoid: 11.3% vs 2.0%; RR, 5.55; 95% CI, 1.66-18.55). At age 12 months, the MEC and MEE groups did not differ significantly in EA (9.3% vs 7.6%; RR, 1.22; 95% CI, 0.62-2.40) or sensitization to egg white (62.8% vs 58.7%; RR, 1.07; 95% CI, 0.91-1.26). No adverse effects were reported. CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, EA development and sensitization to eggs were unaffected by MEC during the early neonatal period. TRIAL REGISTRATION: UMIN Clinical Trials Registry: UMIN000027593 American Medical Association 2023-07-10 /pmc/articles/PMC10334231/ /pubmed/37428506 http://dx.doi.org/10.1001/jamanetworkopen.2023.22318 Text en Copyright 2023 Nagakura KI et al. JAMA Network Open. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Nagakura, Ken-ichi
Sato, Sakura
Shinahara, Wakako
Kido, Hiroshi
Fujita, Hidetoshi
Yanai, Takanori
Akiyama, Nao
Futamura, Masaki
Koga, Hiroshi
Fujiwara, Michimasa
Kaneko, Hideo
Taniguchi, Hiroaki
Makita, Eishi
Takahashi, Kyohei
Yanagida, Noriyuki
Ebisawa, Motohiro
Urashima, Mitsuyoshi
Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial
title Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial
title_full Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial
title_fullStr Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial
title_full_unstemmed Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial
title_short Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial
title_sort effect of maternal egg intake during the early neonatal period and risk of infant egg allergy at 12 months among breastfeeding mothers: a randomized clinical trial
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334231/
https://www.ncbi.nlm.nih.gov/pubmed/37428506
http://dx.doi.org/10.1001/jamanetworkopen.2023.22318
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