Cargando…
Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases
Atherosclerotic cardiovascular disease (ASCVD) frequently results in sudden death and poses a serious threat to public health worldwide. The drugs approved for the prevention and treatment of ASCVD are usually used in combination but are inefficient owing to their side effects and single therapeutic...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Xi'an Jiaotong University
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334359/ https://www.ncbi.nlm.nih.gov/pubmed/37440909 http://dx.doi.org/10.1016/j.jpha.2023.05.010 |
_version_ | 1785070840816074752 |
---|---|
author | Gou, Tingting Hu, Minghao Xu, Min Chen, Yuchen Chen, Rong Zhou, Tao Liu, Junjing Guo, Li Ao, Hui Ye, Qiang |
author_facet | Gou, Tingting Hu, Minghao Xu, Min Chen, Yuchen Chen, Rong Zhou, Tao Liu, Junjing Guo, Li Ao, Hui Ye, Qiang |
author_sort | Gou, Tingting |
collection | PubMed |
description | Atherosclerotic cardiovascular disease (ASCVD) frequently results in sudden death and poses a serious threat to public health worldwide. The drugs approved for the prevention and treatment of ASCVD are usually used in combination but are inefficient owing to their side effects and single therapeutic targets. Therefore, the use of natural products in developing drugs for the prevention and treatment of ASCVD has received great scholarly attention. Andrographolide (AG) is a diterpenoid lactone compound extracted from Andrographis paniculata. In addition to its use in conditions such as sore throat, AG can be used to prevent and treat ASCVD. It is different from drugs that are commonly used in the prevention and treatment of ASCVD and can not only treat obesity, diabetes, hyperlipidaemia and ASCVD but also inhibit the pathological process of atherosclerosis (AS) including lipid accumulation, inflammation, oxidative stress and cellular abnormalities by regulating various targets and pathways. However, the pharmacological mechanisms of AG underlying the prevention and treatment of ASCVD have not been corroborated, which may hinder its clinical development and application. Therefore, this review summarizes the physiological and pathological mechanisms underlying the development of ASCVD and the in vivo and in vitro pharmacological effects of AG on the relative risk factors of AS and ASCVD. The findings support the use of the old pharmacological compound (‘old bottle’) as a novel drug (‘novel wine’) for the prevention and treatment of ASCVD. Additionally, this review summarizes studies on the availability as well as pharmaceutical and pharmacokinetic properties of AG, aiming to provide more information regarding the clinical application and further research and development of AG. |
format | Online Article Text |
id | pubmed-10334359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Xi'an Jiaotong University |
record_format | MEDLINE/PubMed |
spelling | pubmed-103343592023-07-12 Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases Gou, Tingting Hu, Minghao Xu, Min Chen, Yuchen Chen, Rong Zhou, Tao Liu, Junjing Guo, Li Ao, Hui Ye, Qiang J Pharm Anal Review Paper Atherosclerotic cardiovascular disease (ASCVD) frequently results in sudden death and poses a serious threat to public health worldwide. The drugs approved for the prevention and treatment of ASCVD are usually used in combination but are inefficient owing to their side effects and single therapeutic targets. Therefore, the use of natural products in developing drugs for the prevention and treatment of ASCVD has received great scholarly attention. Andrographolide (AG) is a diterpenoid lactone compound extracted from Andrographis paniculata. In addition to its use in conditions such as sore throat, AG can be used to prevent and treat ASCVD. It is different from drugs that are commonly used in the prevention and treatment of ASCVD and can not only treat obesity, diabetes, hyperlipidaemia and ASCVD but also inhibit the pathological process of atherosclerosis (AS) including lipid accumulation, inflammation, oxidative stress and cellular abnormalities by regulating various targets and pathways. However, the pharmacological mechanisms of AG underlying the prevention and treatment of ASCVD have not been corroborated, which may hinder its clinical development and application. Therefore, this review summarizes the physiological and pathological mechanisms underlying the development of ASCVD and the in vivo and in vitro pharmacological effects of AG on the relative risk factors of AS and ASCVD. The findings support the use of the old pharmacological compound (‘old bottle’) as a novel drug (‘novel wine’) for the prevention and treatment of ASCVD. Additionally, this review summarizes studies on the availability as well as pharmaceutical and pharmacokinetic properties of AG, aiming to provide more information regarding the clinical application and further research and development of AG. Xi'an Jiaotong University 2023-06 2023-05-20 /pmc/articles/PMC10334359/ /pubmed/37440909 http://dx.doi.org/10.1016/j.jpha.2023.05.010 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Paper Gou, Tingting Hu, Minghao Xu, Min Chen, Yuchen Chen, Rong Zhou, Tao Liu, Junjing Guo, Li Ao, Hui Ye, Qiang Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases |
title | Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases |
title_full | Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases |
title_fullStr | Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases |
title_full_unstemmed | Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases |
title_short | Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases |
title_sort | novel wine in an old bottle: preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334359/ https://www.ncbi.nlm.nih.gov/pubmed/37440909 http://dx.doi.org/10.1016/j.jpha.2023.05.010 |
work_keys_str_mv | AT goutingting novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases AT huminghao novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases AT xumin novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases AT chenyuchen novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases AT chenrong novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases AT zhoutao novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases AT liujunjing novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases AT guoli novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases AT aohui novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases AT yeqiang novelwineinanoldbottlepreventiveandtherapeuticpotentialsofandrographolideinatheroscleroticcardiovasculardiseases |