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Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness

BACKGROUND: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV. METHODS: Using administrative data and nasopharyngeal swa...

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Autores principales: ElSherif, May, Andrew, Melissa K, Ye, Lingyun, Ambrose, Ardith, Boivin, Guy, Bowie, William, David, Marie-Pierre, Gruselle, Olivier, Halperin, Scott A, Hatchette, Todd F, Johnstone, Jennie, Katz, Kevin, Langley, Joanne M, Loeb, Mark, MacKinnon-Cameron, Donna, McCarthy, Anne, McElhaney, Janet E, McGeer, Allison, Poirier, Andre, Pirçon, Jean-Yves, Powis, Jeff, Richardson, David, Semret, Makeda, Smith, Stephanie, Smyth, Daniel, Trottier, Sylvie, Valiquette, Louis, Webster, Duncan, McNeil, Shelly A, LeBlanc, Jason J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334379/
https://www.ncbi.nlm.nih.gov/pubmed/37441353
http://dx.doi.org/10.1093/ofid/ofad315
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author ElSherif, May
Andrew, Melissa K
Ye, Lingyun
Ambrose, Ardith
Boivin, Guy
Bowie, William
David, Marie-Pierre
Gruselle, Olivier
Halperin, Scott A
Hatchette, Todd F
Johnstone, Jennie
Katz, Kevin
Langley, Joanne M
Loeb, Mark
MacKinnon-Cameron, Donna
McCarthy, Anne
McElhaney, Janet E
McGeer, Allison
Poirier, Andre
Pirçon, Jean-Yves
Powis, Jeff
Richardson, David
Semret, Makeda
Smith, Stephanie
Smyth, Daniel
Trottier, Sylvie
Valiquette, Louis
Webster, Duncan
McNeil, Shelly A
LeBlanc, Jason J
author_facet ElSherif, May
Andrew, Melissa K
Ye, Lingyun
Ambrose, Ardith
Boivin, Guy
Bowie, William
David, Marie-Pierre
Gruselle, Olivier
Halperin, Scott A
Hatchette, Todd F
Johnstone, Jennie
Katz, Kevin
Langley, Joanne M
Loeb, Mark
MacKinnon-Cameron, Donna
McCarthy, Anne
McElhaney, Janet E
McGeer, Allison
Poirier, Andre
Pirçon, Jean-Yves
Powis, Jeff
Richardson, David
Semret, Makeda
Smith, Stephanie
Smyth, Daniel
Trottier, Sylvie
Valiquette, Louis
Webster, Duncan
McNeil, Shelly A
LeBlanc, Jason J
author_sort ElSherif, May
collection PubMed
description BACKGROUND: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV. METHODS: Using administrative data and nasopharyngeal swabs collected from active surveillance among adults aged ≥50 years hospitalized with an acute respiratory illness (ARI) during the 2012–2013, 2013–2014, and 2014–2015 influenza seasons, RSV was identified using a respiratory virus multiplex polymerase chain reaction test to describe the associated disease burden, incidence, and healthcare costs. RESULTS: Of 7797 patients tested, 371 (4.8%) were RSV positive (2.2% RSV-A and 2.6% RSV-B). RSV prevalence varied by season from 4.2% to 6.2%. Respiratory virus coinfection was observed in 11.6% (43/371) of RSV cases, with influenza A being the most common. RSV hospitalization rates varied between seasons and increased with age, from 8–12 per 100 000 population in adults aged 50–59 years to 174–487 per 100 000 in adults aged ≥80 years. The median age of RSV cases was 74.9 years, 63.7% were female, and 98.1% of cases had ≥1 comorbidity. Among RSV cases, the mean length of hospital stay was 10.6 days, 13.7% were admitted to the intensive care unit, 6.4% required mechanical ventilation, and 6.1% died. The mean cost per RSV case was $13 602 (Canadian dollars) but varied by age and Canadian province. CONCLUSIONS: This study adds to the growing literature on adult RSV burden by showing considerable morbidity, mortality, and healthcare costs in hospitalized adults aged ≥50 years with ARIs such as influenza.
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spelling pubmed-103343792023-07-12 Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness ElSherif, May Andrew, Melissa K Ye, Lingyun Ambrose, Ardith Boivin, Guy Bowie, William David, Marie-Pierre Gruselle, Olivier Halperin, Scott A Hatchette, Todd F Johnstone, Jennie Katz, Kevin Langley, Joanne M Loeb, Mark MacKinnon-Cameron, Donna McCarthy, Anne McElhaney, Janet E McGeer, Allison Poirier, Andre Pirçon, Jean-Yves Powis, Jeff Richardson, David Semret, Makeda Smith, Stephanie Smyth, Daniel Trottier, Sylvie Valiquette, Louis Webster, Duncan McNeil, Shelly A LeBlanc, Jason J Open Forum Infect Dis Major Article BACKGROUND: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV. METHODS: Using administrative data and nasopharyngeal swabs collected from active surveillance among adults aged ≥50 years hospitalized with an acute respiratory illness (ARI) during the 2012–2013, 2013–2014, and 2014–2015 influenza seasons, RSV was identified using a respiratory virus multiplex polymerase chain reaction test to describe the associated disease burden, incidence, and healthcare costs. RESULTS: Of 7797 patients tested, 371 (4.8%) were RSV positive (2.2% RSV-A and 2.6% RSV-B). RSV prevalence varied by season from 4.2% to 6.2%. Respiratory virus coinfection was observed in 11.6% (43/371) of RSV cases, with influenza A being the most common. RSV hospitalization rates varied between seasons and increased with age, from 8–12 per 100 000 population in adults aged 50–59 years to 174–487 per 100 000 in adults aged ≥80 years. The median age of RSV cases was 74.9 years, 63.7% were female, and 98.1% of cases had ≥1 comorbidity. Among RSV cases, the mean length of hospital stay was 10.6 days, 13.7% were admitted to the intensive care unit, 6.4% required mechanical ventilation, and 6.1% died. The mean cost per RSV case was $13 602 (Canadian dollars) but varied by age and Canadian province. CONCLUSIONS: This study adds to the growing literature on adult RSV burden by showing considerable morbidity, mortality, and healthcare costs in hospitalized adults aged ≥50 years with ARIs such as influenza. Oxford University Press 2023-06-13 /pmc/articles/PMC10334379/ /pubmed/37441353 http://dx.doi.org/10.1093/ofid/ofad315 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Article
ElSherif, May
Andrew, Melissa K
Ye, Lingyun
Ambrose, Ardith
Boivin, Guy
Bowie, William
David, Marie-Pierre
Gruselle, Olivier
Halperin, Scott A
Hatchette, Todd F
Johnstone, Jennie
Katz, Kevin
Langley, Joanne M
Loeb, Mark
MacKinnon-Cameron, Donna
McCarthy, Anne
McElhaney, Janet E
McGeer, Allison
Poirier, Andre
Pirçon, Jean-Yves
Powis, Jeff
Richardson, David
Semret, Makeda
Smith, Stephanie
Smyth, Daniel
Trottier, Sylvie
Valiquette, Louis
Webster, Duncan
McNeil, Shelly A
LeBlanc, Jason J
Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
title Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
title_full Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
title_fullStr Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
title_full_unstemmed Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
title_short Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
title_sort leveraging influenza virus surveillance from 2012 to 2015 to characterize the burden of respiratory syncytial virus disease in canadian adults ≥50 years of age hospitalized with acute respiratory illness
topic Major Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334379/
https://www.ncbi.nlm.nih.gov/pubmed/37441353
http://dx.doi.org/10.1093/ofid/ofad315
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