Cargando…
Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
BACKGROUND: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV. METHODS: Using administrative data and nasopharyngeal swa...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334379/ https://www.ncbi.nlm.nih.gov/pubmed/37441353 http://dx.doi.org/10.1093/ofid/ofad315 |
_version_ | 1785070845269377024 |
---|---|
author | ElSherif, May Andrew, Melissa K Ye, Lingyun Ambrose, Ardith Boivin, Guy Bowie, William David, Marie-Pierre Gruselle, Olivier Halperin, Scott A Hatchette, Todd F Johnstone, Jennie Katz, Kevin Langley, Joanne M Loeb, Mark MacKinnon-Cameron, Donna McCarthy, Anne McElhaney, Janet E McGeer, Allison Poirier, Andre Pirçon, Jean-Yves Powis, Jeff Richardson, David Semret, Makeda Smith, Stephanie Smyth, Daniel Trottier, Sylvie Valiquette, Louis Webster, Duncan McNeil, Shelly A LeBlanc, Jason J |
author_facet | ElSherif, May Andrew, Melissa K Ye, Lingyun Ambrose, Ardith Boivin, Guy Bowie, William David, Marie-Pierre Gruselle, Olivier Halperin, Scott A Hatchette, Todd F Johnstone, Jennie Katz, Kevin Langley, Joanne M Loeb, Mark MacKinnon-Cameron, Donna McCarthy, Anne McElhaney, Janet E McGeer, Allison Poirier, Andre Pirçon, Jean-Yves Powis, Jeff Richardson, David Semret, Makeda Smith, Stephanie Smyth, Daniel Trottier, Sylvie Valiquette, Louis Webster, Duncan McNeil, Shelly A LeBlanc, Jason J |
author_sort | ElSherif, May |
collection | PubMed |
description | BACKGROUND: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV. METHODS: Using administrative data and nasopharyngeal swabs collected from active surveillance among adults aged ≥50 years hospitalized with an acute respiratory illness (ARI) during the 2012–2013, 2013–2014, and 2014–2015 influenza seasons, RSV was identified using a respiratory virus multiplex polymerase chain reaction test to describe the associated disease burden, incidence, and healthcare costs. RESULTS: Of 7797 patients tested, 371 (4.8%) were RSV positive (2.2% RSV-A and 2.6% RSV-B). RSV prevalence varied by season from 4.2% to 6.2%. Respiratory virus coinfection was observed in 11.6% (43/371) of RSV cases, with influenza A being the most common. RSV hospitalization rates varied between seasons and increased with age, from 8–12 per 100 000 population in adults aged 50–59 years to 174–487 per 100 000 in adults aged ≥80 years. The median age of RSV cases was 74.9 years, 63.7% were female, and 98.1% of cases had ≥1 comorbidity. Among RSV cases, the mean length of hospital stay was 10.6 days, 13.7% were admitted to the intensive care unit, 6.4% required mechanical ventilation, and 6.1% died. The mean cost per RSV case was $13 602 (Canadian dollars) but varied by age and Canadian province. CONCLUSIONS: This study adds to the growing literature on adult RSV burden by showing considerable morbidity, mortality, and healthcare costs in hospitalized adults aged ≥50 years with ARIs such as influenza. |
format | Online Article Text |
id | pubmed-10334379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103343792023-07-12 Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness ElSherif, May Andrew, Melissa K Ye, Lingyun Ambrose, Ardith Boivin, Guy Bowie, William David, Marie-Pierre Gruselle, Olivier Halperin, Scott A Hatchette, Todd F Johnstone, Jennie Katz, Kevin Langley, Joanne M Loeb, Mark MacKinnon-Cameron, Donna McCarthy, Anne McElhaney, Janet E McGeer, Allison Poirier, Andre Pirçon, Jean-Yves Powis, Jeff Richardson, David Semret, Makeda Smith, Stephanie Smyth, Daniel Trottier, Sylvie Valiquette, Louis Webster, Duncan McNeil, Shelly A LeBlanc, Jason J Open Forum Infect Dis Major Article BACKGROUND: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV. METHODS: Using administrative data and nasopharyngeal swabs collected from active surveillance among adults aged ≥50 years hospitalized with an acute respiratory illness (ARI) during the 2012–2013, 2013–2014, and 2014–2015 influenza seasons, RSV was identified using a respiratory virus multiplex polymerase chain reaction test to describe the associated disease burden, incidence, and healthcare costs. RESULTS: Of 7797 patients tested, 371 (4.8%) were RSV positive (2.2% RSV-A and 2.6% RSV-B). RSV prevalence varied by season from 4.2% to 6.2%. Respiratory virus coinfection was observed in 11.6% (43/371) of RSV cases, with influenza A being the most common. RSV hospitalization rates varied between seasons and increased with age, from 8–12 per 100 000 population in adults aged 50–59 years to 174–487 per 100 000 in adults aged ≥80 years. The median age of RSV cases was 74.9 years, 63.7% were female, and 98.1% of cases had ≥1 comorbidity. Among RSV cases, the mean length of hospital stay was 10.6 days, 13.7% were admitted to the intensive care unit, 6.4% required mechanical ventilation, and 6.1% died. The mean cost per RSV case was $13 602 (Canadian dollars) but varied by age and Canadian province. CONCLUSIONS: This study adds to the growing literature on adult RSV burden by showing considerable morbidity, mortality, and healthcare costs in hospitalized adults aged ≥50 years with ARIs such as influenza. Oxford University Press 2023-06-13 /pmc/articles/PMC10334379/ /pubmed/37441353 http://dx.doi.org/10.1093/ofid/ofad315 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Article ElSherif, May Andrew, Melissa K Ye, Lingyun Ambrose, Ardith Boivin, Guy Bowie, William David, Marie-Pierre Gruselle, Olivier Halperin, Scott A Hatchette, Todd F Johnstone, Jennie Katz, Kevin Langley, Joanne M Loeb, Mark MacKinnon-Cameron, Donna McCarthy, Anne McElhaney, Janet E McGeer, Allison Poirier, Andre Pirçon, Jean-Yves Powis, Jeff Richardson, David Semret, Makeda Smith, Stephanie Smyth, Daniel Trottier, Sylvie Valiquette, Louis Webster, Duncan McNeil, Shelly A LeBlanc, Jason J Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness |
title | Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness |
title_full | Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness |
title_fullStr | Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness |
title_full_unstemmed | Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness |
title_short | Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness |
title_sort | leveraging influenza virus surveillance from 2012 to 2015 to characterize the burden of respiratory syncytial virus disease in canadian adults ≥50 years of age hospitalized with acute respiratory illness |
topic | Major Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334379/ https://www.ncbi.nlm.nih.gov/pubmed/37441353 http://dx.doi.org/10.1093/ofid/ofad315 |
work_keys_str_mv | AT elsherifmay leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT andrewmelissak leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT yelingyun leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT ambroseardith leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT boivinguy leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT bowiewilliam leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT davidmariepierre leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT gruselleolivier leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT halperinscotta leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT hatchettetoddf leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT johnstonejennie leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT katzkevin leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT langleyjoannem leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT loebmark leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT mackinnoncamerondonna leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT mccarthyanne leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT mcelhaneyjanete leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT mcgeerallison leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT poirierandre leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT pirconjeanyves leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT powisjeff leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT richardsondavid leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT semretmakeda leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT smithstephanie leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT smythdaniel leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT trottiersylvie leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT valiquettelouis leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT websterduncan leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT mcneilshellya leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT leblancjasonj leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness AT leveraginginfluenzavirussurveillancefrom2012to2015tocharacterizetheburdenofrespiratorysyncytialvirusdiseaseincanadianadults50yearsofagehospitalizedwithacuterespiratoryillness |