Design and Rationale of the APPELHUS Phase 3 Open-Label Study of Factor B Inhibitor Iptacopan for Atypical Hemolytic Uremic Syndrome

INTRODUCTION: Atypical hemolytic uremic syndrome (aHUS) is a rare, progressive, and life-threatening form of thrombotic microangiopathy (TMA) which is caused by dysregulation of the alternative complement pathway (AP). Complement inhibition is an effective therapeutic strategy in aHUS, though curren...

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Detalles Bibliográficos
Autores principales: Kavanagh, David, Greenbaum, Larry A., Bagga, Arvind, Karki, Rajeshri G., Chen, Chien-Wei, Vasudevan, Sajita, Charney, Alan, Dahlke, Marion, Fakhouri, Fadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334406/
https://www.ncbi.nlm.nih.gov/pubmed/37441479
http://dx.doi.org/10.1016/j.ekir.2023.04.029

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