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Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition
PURPOSE: VERDICT (Vascular, Extracellular, Restricted Diffusion for Cytometry in Tumours) MRI is a multi b-value, variable diffusion time DWI sequence that allows generation of ADC maps from different b-value and diffusion time combinations. The aim was to assess precision of prostate ADC measuremen...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334409/ https://www.ncbi.nlm.nih.gov/pubmed/37004362 http://dx.doi.org/10.1016/j.ejrad.2023.110782 |
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author | Rogers, Harriet J. Singh, Saurabh Barnes, Anna Obuchowski, Nancy A. Margolis, Daniel J. Malyarenko, Dariya I. Chenevert, Thomas L. Shukla-Dave, Amita Boss, Michael A. Punwani, Shonit |
author_facet | Rogers, Harriet J. Singh, Saurabh Barnes, Anna Obuchowski, Nancy A. Margolis, Daniel J. Malyarenko, Dariya I. Chenevert, Thomas L. Shukla-Dave, Amita Boss, Michael A. Punwani, Shonit |
author_sort | Rogers, Harriet J. |
collection | PubMed |
description | PURPOSE: VERDICT (Vascular, Extracellular, Restricted Diffusion for Cytometry in Tumours) MRI is a multi b-value, variable diffusion time DWI sequence that allows generation of ADC maps from different b-value and diffusion time combinations. The aim was to assess precision of prostate ADC measurements from varying b-value combinations using VERDICT and determine which protocol provides the most repeatable ADC. MATERIALS AND METHODS: Forty-one men (median age: 67.7 years) from a prior prospective VERDICT study (April 2016–October 2017) were analysed retrospectively. Men who were suspected of prostate cancer and scanned twice using VERDICT were included. ADC maps were formed using 5b-value combinations and the within-subject standard deviations (wSD) were calculated per ADC map. Three anatomical locations were analysed per subject: normal TZ (transition zone), normal PZ (peripheral zone), and index lesions. Repeated measures ANOVAs showed which b-value range had the lowest wSD, Spearman correlation and generalized linear model regression analysis determined whether wSD was related to ADC magnitude and ROI size. RESULTS: The mean lesion ADC for b(0) b(1500) had the lowest wSD in most zones (0.18–0.58x10(−4) mm(2)/s). The wSD was unaffected by ADC magnitude (Lesion: p = 0.064, TZ: p = 0.368, PZ: p = 0.072) and lesion Likert score (p = 0.95). wSD showed a decrease with ROI size pooled over zones (p = 0.019, adjusted regression coefficient = −1.6x10(−3), larger ROIs for TZ versus PZ versus lesions). ADC maps formed with a maximum b-value of 500 s/mm(2) had the largest wSDs (1.90–10.24x10(−4) mm(2)/s). CONCLUSION: ADC maps generated from b(0) b(1500) have better repeatability in normal TZ, normal PZ, and index lesions. |
format | Online Article Text |
id | pubmed-10334409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-103344092023-07-11 Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition Rogers, Harriet J. Singh, Saurabh Barnes, Anna Obuchowski, Nancy A. Margolis, Daniel J. Malyarenko, Dariya I. Chenevert, Thomas L. Shukla-Dave, Amita Boss, Michael A. Punwani, Shonit Eur J Radiol Article PURPOSE: VERDICT (Vascular, Extracellular, Restricted Diffusion for Cytometry in Tumours) MRI is a multi b-value, variable diffusion time DWI sequence that allows generation of ADC maps from different b-value and diffusion time combinations. The aim was to assess precision of prostate ADC measurements from varying b-value combinations using VERDICT and determine which protocol provides the most repeatable ADC. MATERIALS AND METHODS: Forty-one men (median age: 67.7 years) from a prior prospective VERDICT study (April 2016–October 2017) were analysed retrospectively. Men who were suspected of prostate cancer and scanned twice using VERDICT were included. ADC maps were formed using 5b-value combinations and the within-subject standard deviations (wSD) were calculated per ADC map. Three anatomical locations were analysed per subject: normal TZ (transition zone), normal PZ (peripheral zone), and index lesions. Repeated measures ANOVAs showed which b-value range had the lowest wSD, Spearman correlation and generalized linear model regression analysis determined whether wSD was related to ADC magnitude and ROI size. RESULTS: The mean lesion ADC for b(0) b(1500) had the lowest wSD in most zones (0.18–0.58x10(−4) mm(2)/s). The wSD was unaffected by ADC magnitude (Lesion: p = 0.064, TZ: p = 0.368, PZ: p = 0.072) and lesion Likert score (p = 0.95). wSD showed a decrease with ROI size pooled over zones (p = 0.019, adjusted regression coefficient = −1.6x10(−3), larger ROIs for TZ versus PZ versus lesions). ADC maps formed with a maximum b-value of 500 s/mm(2) had the largest wSDs (1.90–10.24x10(−4) mm(2)/s). CONCLUSION: ADC maps generated from b(0) b(1500) have better repeatability in normal TZ, normal PZ, and index lesions. 2023-05 2023-03-16 /pmc/articles/PMC10334409/ /pubmed/37004362 http://dx.doi.org/10.1016/j.ejrad.2023.110782 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Rogers, Harriet J. Singh, Saurabh Barnes, Anna Obuchowski, Nancy A. Margolis, Daniel J. Malyarenko, Dariya I. Chenevert, Thomas L. Shukla-Dave, Amita Boss, Michael A. Punwani, Shonit Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition |
title | Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition |
title_full | Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition |
title_fullStr | Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition |
title_full_unstemmed | Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition |
title_short | Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition |
title_sort | test-retest repeatability of adc in prostate using the multi b-value verdict acquisition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334409/ https://www.ncbi.nlm.nih.gov/pubmed/37004362 http://dx.doi.org/10.1016/j.ejrad.2023.110782 |
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