Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo

ABSTRACT: Cytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein TDP-43 are found in ~ 90% of cases of amyotrophic lateral sclerosis and ~ 45% of patients living with frontotemporal lobar degeneration, but no disease-modifying therapy is available. Antibody therapy targ...

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Autores principales: Riemenschneider, Henrick, Simonetti, Francesca, Sheth, Udit, Katona, Eszter, Roth, Stefan, Hutten, Saskia, Farny, Daniel, Michaelsen, Meike, Nuscher, Brigitte, Schmidt, Michael K., Flatley, Andrew, Schepers, Aloys, Gruijs da Silva, Lara A., Zhou, Qihui, Klopstock, Thomas, Liesz, Arthur, Arzberger, Thomas, Herms, Jochen, Feederle, Regina, Gendron, Tania F., Dormann, Dorothee, Edbauer, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334564/
https://www.ncbi.nlm.nih.gov/pubmed/37434215
http://dx.doi.org/10.1186/s40478-023-01592-z

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