Cargando…

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Background: Extracellular vesicles (EVs) carry bioactive molecules associated with various biological processes, including miRNAs. In both Huntington's disease (HD) models and human samples, altered expression of miRNAs involved in synapse regulation was reported. Recently, the use of EV cargo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beatriz, Margarida, Rodrigues, Ricardo J., Vilaça, Rita, Egas, Conceição, Pinheiro, Paulo S., Daley, George Q., Schlaeger, Thorsten M., Raimundo, Nuno, Rego, A. Cristina, Lopes, Carla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334823/ https://www.ncbi.nlm.nih.gov/pubmed/37441602 http://dx.doi.org/10.7150/thno.81981

Ejemplares similares

Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons
por: Inglis, George Andrew S, et al.
Publicado: (2020)

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting
por: Lopes, Carla, et al.
Publicado: (2020)

Amelioration of Huntington’s disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington’s disease monkeys
por: Cho, In Ki, et al.
Publicado: (2019)

Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites
Publicado: (2020)

Characterization of Neurodevelopmental Abnormalities in iPSC-Derived Striatal Cultures from Patients with Huntington’s Disease
por: Mathkar, Pranav P., et al.
Publicado: (2019)

Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease
por: Linville, Raleigh M., et al.
Publicado: (2022)

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia
por: Stöberl, Nina, et al.
Publicado: (2023)

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
por: Reyes-Ortiz, Andrea M., et al.
Publicado: (2022)

CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons
por: Wu, Gong-Her, et al.
Publicado: (2023)

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
por: Lafaille, Fabien G, et al.
Publicado: (2012)

Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation
por: Simão, Daniel, et al.
Publicado: (2018)

Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation
por: Smith-Geater, Charlene, et al.
Publicado: (2020)

Huntington’s disease iPSC models—using human patient cells to understand the pathology caused by expanded CAG repeats
por: Kaye, Julia, et al.
Publicado: (2022)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

iPSC Bioprinting: Where are We at?
por: Romanazzo, Sara, et al.
Publicado: (2019)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

iPSC for modeling neurodegenerative disorders
por: Valadez-Barba, Valeria, et al.
Publicado: (2020)

Innate immune activation and aberrant function in the R6/2 mouse model and Huntington’s disease iPSC-derived microglia
por: Gasser, Julien, et al.
Publicado: (2023)

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
por: Hedegaard, Anne, et al.
Publicado: (2020)

iPSC-based model of viral infection
Publicado: (2012)

Chromatin looping is needed for iPSC induction
por: Hu, Ji-Fan, et al.
Publicado: (2014)

iPSC-MSCs and islet allograft tolerance
por: Wang, Tong-Song, et al.
Publicado: (2015)

Human iPSC banking: barriers and opportunities
por: Huang, Ching-Ying, et al.
Publicado: (2019)

Application of iPSC to Modelling of Respiratory Diseases
por: Calvert, Ben A., et al.
Publicado: (2020)

The Utilisation of Hydrogels for iPSC-Cardiomyocyte Research
por: Patel, Leena, et al.
Publicado: (2023)

Quantitative comparison of the mRNA content of human iPSC‐derived motor neurons and their extracellular vesicles
por: Otake, Kentaro, et al.
Publicado: (2021)

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits
por: Lim, Ryan G., et al.
Publicado: (2017)

Patient-Specific iPSC-Based Models of Huntington’s Disease as a Tool to Study Store-Operated Calcium Entry Drug Targeting
por: Vigont, Vladimir, et al.
Publicado: (2018)

Three-dimensional brain-on-chip model using human iPSC-derived GABAergic neurons and astrocytes: Butyrylcholinesterase post-treatment for acute malathion exposure
por: Liu, Lumei, et al.
Publicado: (2020)

Identifying the dynamics of actin and tubulin polymerization in iPSCs and in iPSC-derived neurons
por: Magliocca, Valentina, et al.
Publicado: (2017)

Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjögren's Syndrome
por: Hai, Bo, et al.
Publicado: (2018)

Therapeutic Potential of a Combination of Electroacupuncture and Human iPSC-Derived Small Extracellular Vesicles for Ischemic Stroke
por: Deng, Peiying, et al.
Publicado: (2022)

iPSC-derived model of long QT syndrome
Publicado: (2012)

Liver cell reprogramming: Parallels with iPSC biology
por: Yanger, Kilangsungla, et al.
Publicado: (2014)

iPSC technology‐based regenerative therapy for diabetes
por: Kondo, Yasushi, et al.
Publicado: (2017)

The iPSC Awakens ANGPTL3 in Tangier Disease
por: Lee, Man K.S., et al.
Publicado: (2017)

Modeling of Frontotemporal Dementia Using iPSC Technology
por: Kim, Minchul, et al.
Publicado: (2020)

Progress in iPSC-Based Modeling of Psychiatric Disorders
por: Hoffmann, Anke, et al.
Publicado: (2019)

Recent progress of iPSC technology in cardiac diseases
por: Funakoshi, Shunsuke, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ck7ka0hfivgdnvu3dirru1dvsc