Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature

Mannitol is one of the indispensable drugs in neurosurgery to manage the raised intracranial pressure. Though considered safe, extravasation of mannitol into the tissues can cause considerable morbidity with the consequent development of compartment syndrome. We report a case of a 50-year-old female...

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Autores principales: Kaur, Manbir, Balakrishnan, Narayanan, Gosal, Jaskaran Singh, Bhatia, Pradeep, Bhaskar, Suryanarayanan, Jha, Deepak Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AVES 2021
Materias:
Neuroanaesthesia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335528/
https://www.ncbi.nlm.nih.gov/pubmed/35110016
http://dx.doi.org/10.5152/TJAR.2021.570
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author Kaur, Manbir
Balakrishnan, Narayanan
Gosal, Jaskaran Singh
Bhatia, Pradeep
Bhaskar, Suryanarayanan
Jha, Deepak Kumar
author_facet Kaur, Manbir
Balakrishnan, Narayanan
Gosal, Jaskaran Singh
Bhatia, Pradeep
Bhaskar, Suryanarayanan
Jha, Deepak Kumar
author_sort Kaur, Manbir
collection PubMed
description Mannitol is one of the indispensable drugs in neurosurgery to manage the raised intracranial pressure. Though considered safe, extravasation of mannitol into the tissues can cause considerable morbidity with the consequent development of compartment syndrome. We report a case of a 50-year-old female who developed forearm compartment syndrome due to mannitol extravasation after undergoing surgery for frontal glioma under general anaesthesia. The severe forearm compartment syndrome could be successfully managed without fasciotomy using hyaluronidase. We describe the pathophysiology, prevention and treatment strategies emphasising the use of hyaluronidase in the management of mannitol extravasation induced compartment syndrome.
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spelling pubmed-103355282023-07-15 Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature Kaur, Manbir Balakrishnan, Narayanan Gosal, Jaskaran Singh Bhatia, Pradeep Bhaskar, Suryanarayanan Jha, Deepak Kumar Turk J Anaesthesiol Reanim Neuroanaesthesia Mannitol is one of the indispensable drugs in neurosurgery to manage the raised intracranial pressure. Though considered safe, extravasation of mannitol into the tissues can cause considerable morbidity with the consequent development of compartment syndrome. We report a case of a 50-year-old female who developed forearm compartment syndrome due to mannitol extravasation after undergoing surgery for frontal glioma under general anaesthesia. The severe forearm compartment syndrome could be successfully managed without fasciotomy using hyaluronidase. We describe the pathophysiology, prevention and treatment strategies emphasising the use of hyaluronidase in the management of mannitol extravasation induced compartment syndrome. AVES 2021-08-16 /pmc/articles/PMC10335528/ /pubmed/35110016 http://dx.doi.org/10.5152/TJAR.2021.570 Text en © Copyright 2021 by Turkish Society of Anaesthesiology and Reanimation - Available online at www.turkjanaesthesiolreanim.org https://creativecommons.org/licenses/by-nc/4.0/Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
spellingShingle Neuroanaesthesia
Kaur, Manbir
Balakrishnan, Narayanan
Gosal, Jaskaran Singh
Bhatia, Pradeep
Bhaskar, Suryanarayanan
Jha, Deepak Kumar
Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature
title Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature
title_full Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature
title_fullStr Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature
title_full_unstemmed Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature
title_short Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature
title_sort efficacy of hyaluronidase in the mannitol extravasation induced compartment syndrome-a case report and review of literature
topic Neuroanaesthesia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335528/
https://www.ncbi.nlm.nih.gov/pubmed/35110016
http://dx.doi.org/10.5152/TJAR.2021.570
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