Genital ulcers following all-trans-retinoic acid therapy: A case series with review of literature

All-trans-retinoic acid (ATRA) has transformed the treatment of acute promyelocytic leukemia. Most of the adverse effects associated with this drug are minor barring differentiation syndromes. Genital ulcers feature among the underreported adverse effects of ATRA which needs to be kept in mind to av...

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Detalles Bibliográficos
Autores principales: Saraswat, Neerja, Kumar, Sushil, Prem, Rahul, Tripathi, Durga Madhab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335649/
https://www.ncbi.nlm.nih.gov/pubmed/37313940
http://dx.doi.org/10.4103/ijp.ijp_811_21
Descripción
Sumario:All-trans-retinoic acid (ATRA) has transformed the treatment of acute promyelocytic leukemia. Most of the adverse effects associated with this drug are minor barring differentiation syndromes. Genital ulcers feature among the underreported adverse effects of ATRA which needs to be kept in mind to avoid life-threatening complications. We describe two cases who developed genital ulcers while treated with ATRA.

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