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Small regulatory RNAs in Vibrio cholerae
Vibrio cholerae is a major human pathogen causing the diarrheal disease, cholera. Regulation of virulence in V. cholerae is a multifaceted process involving gene expression changes at the transcriptional and post-transcriptional level. Whereas various transcription factors have been reported to modu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335731/ https://www.ncbi.nlm.nih.gov/pubmed/37441523 http://dx.doi.org/10.1093/femsml/uqad030 |
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author | Ghandour, Rabea Papenfort, Kai |
author_facet | Ghandour, Rabea Papenfort, Kai |
author_sort | Ghandour, Rabea |
collection | PubMed |
description | Vibrio cholerae is a major human pathogen causing the diarrheal disease, cholera. Regulation of virulence in V. cholerae is a multifaceted process involving gene expression changes at the transcriptional and post-transcriptional level. Whereas various transcription factors have been reported to modulate virulence in V. cholerae, small regulatory RNAs (sRNAs) have now been established to also participate in virulence control and the regulation of virulence-associated processes, such as biofilm formation, quorum sensing, stress response, and metabolism. In most cases, these sRNAs act by base-pairing with multiple target transcripts and this process typically requires the aid of an RNA-binding protein, such as the widely conserved Hfq protein. This review article summarizes the functional roles of sRNAs in V. cholerae, their underlying mechanisms of gene expression control, and how sRNAs partner with transcription factors to modulate complex regulatory programs. In addition, we will discuss regulatory principles discovered in V. cholerae that not only apply to other Vibrio species, but further extend into the large field of RNA-mediated gene expression control in bacteria. |
format | Online Article Text |
id | pubmed-10335731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103357312023-07-12 Small regulatory RNAs in Vibrio cholerae Ghandour, Rabea Papenfort, Kai Microlife Short Review Vibrio cholerae is a major human pathogen causing the diarrheal disease, cholera. Regulation of virulence in V. cholerae is a multifaceted process involving gene expression changes at the transcriptional and post-transcriptional level. Whereas various transcription factors have been reported to modulate virulence in V. cholerae, small regulatory RNAs (sRNAs) have now been established to also participate in virulence control and the regulation of virulence-associated processes, such as biofilm formation, quorum sensing, stress response, and metabolism. In most cases, these sRNAs act by base-pairing with multiple target transcripts and this process typically requires the aid of an RNA-binding protein, such as the widely conserved Hfq protein. This review article summarizes the functional roles of sRNAs in V. cholerae, their underlying mechanisms of gene expression control, and how sRNAs partner with transcription factors to modulate complex regulatory programs. In addition, we will discuss regulatory principles discovered in V. cholerae that not only apply to other Vibrio species, but further extend into the large field of RNA-mediated gene expression control in bacteria. Oxford University Press 2023-06-15 /pmc/articles/PMC10335731/ /pubmed/37441523 http://dx.doi.org/10.1093/femsml/uqad030 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of FEMS. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Short Review Ghandour, Rabea Papenfort, Kai Small regulatory RNAs in Vibrio cholerae |
title | Small regulatory RNAs in Vibrio cholerae |
title_full | Small regulatory RNAs in Vibrio cholerae |
title_fullStr | Small regulatory RNAs in Vibrio cholerae |
title_full_unstemmed | Small regulatory RNAs in Vibrio cholerae |
title_short | Small regulatory RNAs in Vibrio cholerae |
title_sort | small regulatory rnas in vibrio cholerae |
topic | Short Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335731/ https://www.ncbi.nlm.nih.gov/pubmed/37441523 http://dx.doi.org/10.1093/femsml/uqad030 |
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