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Small regulatory RNAs in Vibrio cholerae

Vibrio cholerae is a major human pathogen causing the diarrheal disease, cholera. Regulation of virulence in V. cholerae is a multifaceted process involving gene expression changes at the transcriptional and post-transcriptional level. Whereas various transcription factors have been reported to modu...

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Detalles Bibliográficos
Autores principales: Ghandour, Rabea, Papenfort, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335731/
https://www.ncbi.nlm.nih.gov/pubmed/37441523
http://dx.doi.org/10.1093/femsml/uqad030
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author Ghandour, Rabea
Papenfort, Kai
author_facet Ghandour, Rabea
Papenfort, Kai
author_sort Ghandour, Rabea
collection PubMed
description Vibrio cholerae is a major human pathogen causing the diarrheal disease, cholera. Regulation of virulence in V. cholerae is a multifaceted process involving gene expression changes at the transcriptional and post-transcriptional level. Whereas various transcription factors have been reported to modulate virulence in V. cholerae, small regulatory RNAs (sRNAs) have now been established to also participate in virulence control and the regulation of virulence-associated processes, such as biofilm formation, quorum sensing, stress response, and metabolism. In most cases, these sRNAs act by base-pairing with multiple target transcripts and this process typically requires the aid of an RNA-binding protein, such as the widely conserved Hfq protein. This review article summarizes the functional roles of sRNAs in V. cholerae, their underlying mechanisms of gene expression control, and how sRNAs partner with transcription factors to modulate complex regulatory programs. In addition, we will discuss regulatory principles discovered in V. cholerae that not only apply to other Vibrio species, but further extend into the large field of RNA-mediated gene expression control in bacteria.
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spelling pubmed-103357312023-07-12 Small regulatory RNAs in Vibrio cholerae Ghandour, Rabea Papenfort, Kai Microlife Short Review Vibrio cholerae is a major human pathogen causing the diarrheal disease, cholera. Regulation of virulence in V. cholerae is a multifaceted process involving gene expression changes at the transcriptional and post-transcriptional level. Whereas various transcription factors have been reported to modulate virulence in V. cholerae, small regulatory RNAs (sRNAs) have now been established to also participate in virulence control and the regulation of virulence-associated processes, such as biofilm formation, quorum sensing, stress response, and metabolism. In most cases, these sRNAs act by base-pairing with multiple target transcripts and this process typically requires the aid of an RNA-binding protein, such as the widely conserved Hfq protein. This review article summarizes the functional roles of sRNAs in V. cholerae, their underlying mechanisms of gene expression control, and how sRNAs partner with transcription factors to modulate complex regulatory programs. In addition, we will discuss regulatory principles discovered in V. cholerae that not only apply to other Vibrio species, but further extend into the large field of RNA-mediated gene expression control in bacteria. Oxford University Press 2023-06-15 /pmc/articles/PMC10335731/ /pubmed/37441523 http://dx.doi.org/10.1093/femsml/uqad030 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of FEMS. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Short Review
Ghandour, Rabea
Papenfort, Kai
Small regulatory RNAs in Vibrio cholerae
title Small regulatory RNAs in Vibrio cholerae
title_full Small regulatory RNAs in Vibrio cholerae
title_fullStr Small regulatory RNAs in Vibrio cholerae
title_full_unstemmed Small regulatory RNAs in Vibrio cholerae
title_short Small regulatory RNAs in Vibrio cholerae
title_sort small regulatory rnas in vibrio cholerae
topic Short Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335731/
https://www.ncbi.nlm.nih.gov/pubmed/37441523
http://dx.doi.org/10.1093/femsml/uqad030
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