A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function

The histone chaperone chromatin assembly factor 1 (CAF-1) deposits two nascent histone H3/H4 dimers onto newly replicated DNA forming the central core of the nucleosome known as the tetrasome. How CAF-1 ensures there is sufficient space for the assembly of tetrasomes remains unknown. Structural and...

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Detalles Bibliográficos
Autores principales: Rosas, Ruben, Aguilar, Rhiannon R, Arslanovic, Nina, Seck, Anna, Smith, Duncan J, Tyler, Jessica K, Churchill, Mair EA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335832/
https://www.ncbi.nlm.nih.gov/pubmed/37432722
http://dx.doi.org/10.7554/eLife.83538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335832/
https://www.ncbi.nlm.nih.gov/pubmed/37432722
http://dx.doi.org/10.7554/eLife.83538

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