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Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing's Disease
PURPOSE: Few related factors of low bone mass in Cushing's disease (CD) have been identified so far, and relevant sufficient powered studies in CD patients are rare. On account of the scarcity of data, we performed a well-powered study to identify related factors associated with low bone mass i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335871/ https://www.ncbi.nlm.nih.gov/pubmed/37441368 http://dx.doi.org/10.1155/2023/3334982 |
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author | Sun, Wanwan Sun, Quanya Cui, Qiaoli He, Min Wu, Wei Li, Yiming Ye, Hongying Zhang, Shuo |
author_facet | Sun, Wanwan Sun, Quanya Cui, Qiaoli He, Min Wu, Wei Li, Yiming Ye, Hongying Zhang, Shuo |
author_sort | Sun, Wanwan |
collection | PubMed |
description | PURPOSE: Few related factors of low bone mass in Cushing's disease (CD) have been identified so far, and relevant sufficient powered studies in CD patients are rare. On account of the scarcity of data, we performed a well-powered study to identify related factors associated with low bone mass in young CD patients. METHODS: This retrospective study included 153 CD patients (33 males and 120 females, under the age of 50 for men and premenopausal women). Bone mineral density (BMD) of the left hip and lumbar spine was measured by dual energy X-ray absorptiometry (DEXA). In this study, low bone mass was defined when the Z score was −2.0 or lower. RESULTS: Among those CD patients, low bone mass occurred in 74 patients (48.37%). Compared to patients with normal BMD, those patients with low bone mass had a higher level of serum cortisol at midnight (22.31 (17.95-29.62) vs. 17.80 (13.75-22.77), p=0.0006), testosterone in women (2.10 (1.33–2.89) vs. 1.54 (0.97–2.05), p=0.0012), higher portion of male (32.43% vs. 11.54%, p=0.0016) as well as hypertension (76.12% vs. 51.67%, p=0.0075), and lower IGF-1 index (0.59 (0.43–0.76) vs. 0.79 (0.60–1.02), p=0.0001). The Z score was positively associated with the IGF-1 index in both the lumbar spine (r = 0.35153, p < 0.0001) and the femoral neck (r = 0.24418, p=0.0057). The Z score in the femoral neck was negatively associated with osteocalcin (r = −0.22744, p=0.0229). Compared to the lowest tertile of the IGF-1 index (<0.5563), the patients with the highest tertile of the IGF-1 index (≥0.7993) had a lower prevalence of low bone mass (95% CI 0.02 (0.001–0.50), p=0.0002), even after adjusting for confounders such as age, gender, duration, BMI, hypertension, serum cortisol at midnight, PTH, and osteocalcin. CONCLUSIONS: The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass. |
format | Online Article Text |
id | pubmed-10335871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-103358712023-07-12 Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing's Disease Sun, Wanwan Sun, Quanya Cui, Qiaoli He, Min Wu, Wei Li, Yiming Ye, Hongying Zhang, Shuo Int J Endocrinol Research Article PURPOSE: Few related factors of low bone mass in Cushing's disease (CD) have been identified so far, and relevant sufficient powered studies in CD patients are rare. On account of the scarcity of data, we performed a well-powered study to identify related factors associated with low bone mass in young CD patients. METHODS: This retrospective study included 153 CD patients (33 males and 120 females, under the age of 50 for men and premenopausal women). Bone mineral density (BMD) of the left hip and lumbar spine was measured by dual energy X-ray absorptiometry (DEXA). In this study, low bone mass was defined when the Z score was −2.0 or lower. RESULTS: Among those CD patients, low bone mass occurred in 74 patients (48.37%). Compared to patients with normal BMD, those patients with low bone mass had a higher level of serum cortisol at midnight (22.31 (17.95-29.62) vs. 17.80 (13.75-22.77), p=0.0006), testosterone in women (2.10 (1.33–2.89) vs. 1.54 (0.97–2.05), p=0.0012), higher portion of male (32.43% vs. 11.54%, p=0.0016) as well as hypertension (76.12% vs. 51.67%, p=0.0075), and lower IGF-1 index (0.59 (0.43–0.76) vs. 0.79 (0.60–1.02), p=0.0001). The Z score was positively associated with the IGF-1 index in both the lumbar spine (r = 0.35153, p < 0.0001) and the femoral neck (r = 0.24418, p=0.0057). The Z score in the femoral neck was negatively associated with osteocalcin (r = −0.22744, p=0.0229). Compared to the lowest tertile of the IGF-1 index (<0.5563), the patients with the highest tertile of the IGF-1 index (≥0.7993) had a lower prevalence of low bone mass (95% CI 0.02 (0.001–0.50), p=0.0002), even after adjusting for confounders such as age, gender, duration, BMI, hypertension, serum cortisol at midnight, PTH, and osteocalcin. CONCLUSIONS: The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass. Hindawi 2023-07-04 /pmc/articles/PMC10335871/ /pubmed/37441368 http://dx.doi.org/10.1155/2023/3334982 Text en Copyright © 2023 Wanwan Sun et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sun, Wanwan Sun, Quanya Cui, Qiaoli He, Min Wu, Wei Li, Yiming Ye, Hongying Zhang, Shuo Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing's Disease |
title | Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing's Disease |
title_full | Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing's Disease |
title_fullStr | Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing's Disease |
title_full_unstemmed | Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing's Disease |
title_short | Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing's Disease |
title_sort | association of igf-1 level with low bone mass in young patients with cushing's disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335871/ https://www.ncbi.nlm.nih.gov/pubmed/37441368 http://dx.doi.org/10.1155/2023/3334982 |
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