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Penile Livedoid Vasculopathy: First Reported Case

Livedoid vasculopathy is a thromboocclusive cutaneous vasculopathy manifested by livedoid changes, atrophie blanche, and ulceration. The pathogenesis is speculated to involve increasing coagulation or impaired thrombolysis leading to the occlusion of dermal blood vessels with fibrin thrombi. Livedoi...

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Autores principales: Hallak, Ahmad, Bennett, William, Tanbir, Mohammed Adib, Donthamsetty, Supriya R., Vincent, Bethaney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335878/
https://www.ncbi.nlm.nih.gov/pubmed/37440957
http://dx.doi.org/10.1155/2023/6920383
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author Hallak, Ahmad
Bennett, William
Tanbir, Mohammed Adib
Donthamsetty, Supriya R.
Vincent, Bethaney
author_facet Hallak, Ahmad
Bennett, William
Tanbir, Mohammed Adib
Donthamsetty, Supriya R.
Vincent, Bethaney
author_sort Hallak, Ahmad
collection PubMed
description Livedoid vasculopathy is a thromboocclusive cutaneous vasculopathy manifested by livedoid changes, atrophie blanche, and ulceration. The pathogenesis is speculated to involve increasing coagulation or impaired thrombolysis leading to the occlusion of dermal blood vessels with fibrin thrombi. Livedoid vasculopathy is known to primarily affect the lower extremities. We report the first case of livedoid vasculopathy affecting the penis. A 60-year-old male was evaluated for a split urine stream with associated irritation and peeling of the skin of the glans penis. His penile ulcer continued to enlarge despite steroids and antibiotics. Due to diagnostic uncertainty, a biopsy was performed which revealed hyaline thrombi within the lumens of small vessels within the upper to mid dermis, fibrinoid material in the walls of these blood vessels and within the perivascular stroma with overlying and adjacent epidermal spongiosis, and mild perivascular lymphocytic infiltrate with a few scattered neutrophils most consistent with livedoid vasculitis. He was started on aspirin and pentoxifylline with limited improvement and was later started on apixaban with near-complete resolution in 6 months. Penile livedoid vasculopathy has not been previously reported in the English literature. Early diagnosis and treatment are imperative to limit morbidity.
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spelling pubmed-103358782023-07-12 Penile Livedoid Vasculopathy: First Reported Case Hallak, Ahmad Bennett, William Tanbir, Mohammed Adib Donthamsetty, Supriya R. Vincent, Bethaney Case Rep Vasc Med Case Report Livedoid vasculopathy is a thromboocclusive cutaneous vasculopathy manifested by livedoid changes, atrophie blanche, and ulceration. The pathogenesis is speculated to involve increasing coagulation or impaired thrombolysis leading to the occlusion of dermal blood vessels with fibrin thrombi. Livedoid vasculopathy is known to primarily affect the lower extremities. We report the first case of livedoid vasculopathy affecting the penis. A 60-year-old male was evaluated for a split urine stream with associated irritation and peeling of the skin of the glans penis. His penile ulcer continued to enlarge despite steroids and antibiotics. Due to diagnostic uncertainty, a biopsy was performed which revealed hyaline thrombi within the lumens of small vessels within the upper to mid dermis, fibrinoid material in the walls of these blood vessels and within the perivascular stroma with overlying and adjacent epidermal spongiosis, and mild perivascular lymphocytic infiltrate with a few scattered neutrophils most consistent with livedoid vasculitis. He was started on aspirin and pentoxifylline with limited improvement and was later started on apixaban with near-complete resolution in 6 months. Penile livedoid vasculopathy has not been previously reported in the English literature. Early diagnosis and treatment are imperative to limit morbidity. Hindawi 2023-07-04 /pmc/articles/PMC10335878/ /pubmed/37440957 http://dx.doi.org/10.1155/2023/6920383 Text en Copyright © 2023 Ahmad Hallak et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hallak, Ahmad
Bennett, William
Tanbir, Mohammed Adib
Donthamsetty, Supriya R.
Vincent, Bethaney
Penile Livedoid Vasculopathy: First Reported Case
title Penile Livedoid Vasculopathy: First Reported Case
title_full Penile Livedoid Vasculopathy: First Reported Case
title_fullStr Penile Livedoid Vasculopathy: First Reported Case
title_full_unstemmed Penile Livedoid Vasculopathy: First Reported Case
title_short Penile Livedoid Vasculopathy: First Reported Case
title_sort penile livedoid vasculopathy: first reported case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335878/
https://www.ncbi.nlm.nih.gov/pubmed/37440957
http://dx.doi.org/10.1155/2023/6920383
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