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Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis

BACKGROUND: Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis. MATERIALS AND METHODS: PubMed, Medline, Embas...

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Autores principales: Wang, Daoqi, Tan, Jiahong, Geng, Erkang, Wan, Chuanping, Xu, Jinming, Yang, Bin, Zhou, Yuan, Zhou, Guiming, Ye, Zhenni, Li, Jiongming, Liu, Jianhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Urologia 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335896/
https://www.ncbi.nlm.nih.gov/pubmed/37115175
http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0587
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author Wang, Daoqi
Tan, Jiahong
Geng, Erkang
Wan, Chuanping
Xu, Jinming
Yang, Bin
Zhou, Yuan
Zhou, Guiming
Ye, Zhenni
Li, Jiongming
Liu, Jianhe
author_facet Wang, Daoqi
Tan, Jiahong
Geng, Erkang
Wan, Chuanping
Xu, Jinming
Yang, Bin
Zhou, Yuan
Zhou, Guiming
Ye, Zhenni
Li, Jiongming
Liu, Jianhe
author_sort Wang, Daoqi
collection PubMed
description BACKGROUND: Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis. MATERIALS AND METHODS: PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software. RESULTS: A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results. CONCLUSIONS: The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones.
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spelling pubmed-103358962023-07-13 Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis Wang, Daoqi Tan, Jiahong Geng, Erkang Wan, Chuanping Xu, Jinming Yang, Bin Zhou, Yuan Zhou, Guiming Ye, Zhenni Li, Jiongming Liu, Jianhe Int Braz J Urol Review Article BACKGROUND: Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis. MATERIALS AND METHODS: PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software. RESULTS: A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results. CONCLUSIONS: The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones. Sociedade Brasileira de Urologia 2023-03-30 /pmc/articles/PMC10335896/ /pubmed/37115175 http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0587 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Daoqi
Tan, Jiahong
Geng, Erkang
Wan, Chuanping
Xu, Jinming
Yang, Bin
Zhou, Yuan
Zhou, Guiming
Ye, Zhenni
Li, Jiongming
Liu, Jianhe
Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis
title Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis
title_full Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis
title_fullStr Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis
title_full_unstemmed Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis
title_short Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis
title_sort impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335896/
https://www.ncbi.nlm.nih.gov/pubmed/37115175
http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0587
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