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Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis
BACKGROUND: Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis. MATERIALS AND METHODS: PubMed, Medline, Embas...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Urologia
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335896/ https://www.ncbi.nlm.nih.gov/pubmed/37115175 http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0587 |
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author | Wang, Daoqi Tan, Jiahong Geng, Erkang Wan, Chuanping Xu, Jinming Yang, Bin Zhou, Yuan Zhou, Guiming Ye, Zhenni Li, Jiongming Liu, Jianhe |
author_facet | Wang, Daoqi Tan, Jiahong Geng, Erkang Wan, Chuanping Xu, Jinming Yang, Bin Zhou, Yuan Zhou, Guiming Ye, Zhenni Li, Jiongming Liu, Jianhe |
author_sort | Wang, Daoqi |
collection | PubMed |
description | BACKGROUND: Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis. MATERIALS AND METHODS: PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software. RESULTS: A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results. CONCLUSIONS: The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones. |
format | Online Article Text |
id | pubmed-10335896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Sociedade Brasileira de Urologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-103358962023-07-13 Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis Wang, Daoqi Tan, Jiahong Geng, Erkang Wan, Chuanping Xu, Jinming Yang, Bin Zhou, Yuan Zhou, Guiming Ye, Zhenni Li, Jiongming Liu, Jianhe Int Braz J Urol Review Article BACKGROUND: Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis. MATERIALS AND METHODS: PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software. RESULTS: A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results. CONCLUSIONS: The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones. Sociedade Brasileira de Urologia 2023-03-30 /pmc/articles/PMC10335896/ /pubmed/37115175 http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0587 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Daoqi Tan, Jiahong Geng, Erkang Wan, Chuanping Xu, Jinming Yang, Bin Zhou, Yuan Zhou, Guiming Ye, Zhenni Li, Jiongming Liu, Jianhe Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
title | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
title_full | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
title_fullStr | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
title_full_unstemmed | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
title_short | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
title_sort | impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335896/ https://www.ncbi.nlm.nih.gov/pubmed/37115175 http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0587 |
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