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Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and “anatomical escape” characteristics threaten the effectiveness of current coronavirus disease 2019 (COVID-19) vaccines. There is an urgent need to understand the immunological mechanism of broad-spectrum respi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336035/ https://www.ncbi.nlm.nih.gov/pubmed/37433761 http://dx.doi.org/10.1038/s41467-023-39560-9 |
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| author | Zhang, Liang Jiang, Yao He, Jinhang Chen, Junyu Qi, Ruoyao Yuan, Lunzhi Shao, Tiange Zhao, Hui Chen, Congjie Chen, Yaode Wang, Xijing Lei, Xing Gao, Qingxiang Zhuang, Chunlan Zhou, Ming Ma, Jian Liu, Wei Yang, Man Fu, Rao Wu, Yangtao Chen, Feng Xiong, Hualong Nie, Meifeng Chen, Yiyi Wu, Kun Fang, Mujin Wang, Yingbin Zheng, Zizheng Huang, Shoujie Ge, Shengxiang Cheng, Shih Chin Zhu, Huachen Cheng, Tong Yuan, Quan Wu, Ting Zhang, Jun Chen, Yixin Zhang, Tianying Li, Changgui Qi, Hai Guan, Yi Xia, Ningshao |
| author_facet | Zhang, Liang Jiang, Yao He, Jinhang Chen, Junyu Qi, Ruoyao Yuan, Lunzhi Shao, Tiange Zhao, Hui Chen, Congjie Chen, Yaode Wang, Xijing Lei, Xing Gao, Qingxiang Zhuang, Chunlan Zhou, Ming Ma, Jian Liu, Wei Yang, Man Fu, Rao Wu, Yangtao Chen, Feng Xiong, Hualong Nie, Meifeng Chen, Yiyi Wu, Kun Fang, Mujin Wang, Yingbin Zheng, Zizheng Huang, Shoujie Ge, Shengxiang Cheng, Shih Chin Zhu, Huachen Cheng, Tong Yuan, Quan Wu, Ting Zhang, Jun Chen, Yixin Zhang, Tianying Li, Changgui Qi, Hai Guan, Yi Xia, Ningshao |
| author_sort | Zhang, Liang |
| collection | PubMed |
| description | The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and “anatomical escape” characteristics threaten the effectiveness of current coronavirus disease 2019 (COVID-19) vaccines. There is an urgent need to understand the immunological mechanism of broad-spectrum respiratory tract protection to guide broader vaccines development. Here we investigate immune responses induced by an NS1-deleted influenza virus vectored intranasal COVID-19 vaccine (dNS1-RBD) which provides broad-spectrum protection against SARS-CoV-2 variants in hamsters. Intranasal delivery of dNS1-RBD induces innate immunity, trained immunity and tissue-resident memory T cells covering the upper and lower respiratory tract. It restrains the inflammatory response by suppressing early phase viral load post SARS-CoV-2 challenge and attenuating pro-inflammatory cytokine (Il6, Il1b, and Ifng) levels, thereby reducing excess immune-induced tissue injury compared with the control group. By inducing local cellular immunity and trained immunity, intranasal delivery of NS1-deleted influenza virus vectored vaccine represents a broad-spectrum COVID-19 vaccine strategy to reduce disease burden. |
| format | Online Article Text |
| id | pubmed-10336035 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103360352023-07-13 Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters Zhang, Liang Jiang, Yao He, Jinhang Chen, Junyu Qi, Ruoyao Yuan, Lunzhi Shao, Tiange Zhao, Hui Chen, Congjie Chen, Yaode Wang, Xijing Lei, Xing Gao, Qingxiang Zhuang, Chunlan Zhou, Ming Ma, Jian Liu, Wei Yang, Man Fu, Rao Wu, Yangtao Chen, Feng Xiong, Hualong Nie, Meifeng Chen, Yiyi Wu, Kun Fang, Mujin Wang, Yingbin Zheng, Zizheng Huang, Shoujie Ge, Shengxiang Cheng, Shih Chin Zhu, Huachen Cheng, Tong Yuan, Quan Wu, Ting Zhang, Jun Chen, Yixin Zhang, Tianying Li, Changgui Qi, Hai Guan, Yi Xia, Ningshao Nat Commun Article The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and “anatomical escape” characteristics threaten the effectiveness of current coronavirus disease 2019 (COVID-19) vaccines. There is an urgent need to understand the immunological mechanism of broad-spectrum respiratory tract protection to guide broader vaccines development. Here we investigate immune responses induced by an NS1-deleted influenza virus vectored intranasal COVID-19 vaccine (dNS1-RBD) which provides broad-spectrum protection against SARS-CoV-2 variants in hamsters. Intranasal delivery of dNS1-RBD induces innate immunity, trained immunity and tissue-resident memory T cells covering the upper and lower respiratory tract. It restrains the inflammatory response by suppressing early phase viral load post SARS-CoV-2 challenge and attenuating pro-inflammatory cytokine (Il6, Il1b, and Ifng) levels, thereby reducing excess immune-induced tissue injury compared with the control group. By inducing local cellular immunity and trained immunity, intranasal delivery of NS1-deleted influenza virus vectored vaccine represents a broad-spectrum COVID-19 vaccine strategy to reduce disease burden. Nature Publishing Group UK 2023-07-11 /pmc/articles/PMC10336035/ /pubmed/37433761 http://dx.doi.org/10.1038/s41467-023-39560-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Zhang, Liang Jiang, Yao He, Jinhang Chen, Junyu Qi, Ruoyao Yuan, Lunzhi Shao, Tiange Zhao, Hui Chen, Congjie Chen, Yaode Wang, Xijing Lei, Xing Gao, Qingxiang Zhuang, Chunlan Zhou, Ming Ma, Jian Liu, Wei Yang, Man Fu, Rao Wu, Yangtao Chen, Feng Xiong, Hualong Nie, Meifeng Chen, Yiyi Wu, Kun Fang, Mujin Wang, Yingbin Zheng, Zizheng Huang, Shoujie Ge, Shengxiang Cheng, Shih Chin Zhu, Huachen Cheng, Tong Yuan, Quan Wu, Ting Zhang, Jun Chen, Yixin Zhang, Tianying Li, Changgui Qi, Hai Guan, Yi Xia, Ningshao Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters |
| title | Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters |
| title_full | Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters |
| title_fullStr | Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters |
| title_full_unstemmed | Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters |
| title_short | Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters |
| title_sort | intranasal influenza-vectored covid-19 vaccine restrains the sars-cov-2 inflammatory response in hamsters |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336035/ https://www.ncbi.nlm.nih.gov/pubmed/37433761 http://dx.doi.org/10.1038/s41467-023-39560-9 |
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